|Description||H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. It inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. It selectively blocks lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.|
|Appearance||White to Off-White Solid|
|Synonyms||(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline dihydrochloride;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride|
|Solubility||DMSO: ≥ 32 mg/mL|
|Storage||Hygroscopic, -20°C Freezer, Under Inert Atmosphere|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
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