H-1152 Dihydrochloride - CAS 871543-07-6
Catalog number: 871543-07-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H23Cl2N3O2S
Molecular Weight:
392.34
COA:
Inquire
Targets:
ROCK
Description:
H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. It inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. It selectively blocks lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
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Purity:
>98 %
Appearance:
White to Off-White Solid
Synonyms:
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine Dihydrochloride;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline dihydrochloride;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride
Solubility:
DMSO: ≥ 32 mg/mL
Storage:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
MSDS:
Inquire
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Melting Point:
182-184°C
InChIKey:
BFOPDSJOLUQULZ-GXKRWWSZSA-N
InChI:
InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
Canonical SMILES:
CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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CAS 871543-07-6 H-1152 Dihydrochloride

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