Gynostemma Extract - CAS 80321-63-7
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Not Intended for Therapeutic Use. For research use only.
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Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.
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1.Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities.
Yang F1, Shi H, Zhang X, Yang H, Zhou Q, Yu LL. Food Chem. 2013 Dec 15;141(4):3606-13. doi: 10.1016/j.foodchem.2013.06.015. Epub 2013 Jun 13.
Jiaogulan tea has been commercialised globally. This study investigated the chemical components and health properties of a new jiaogulan genotype, tetraploid Gynostemma pentaphyllum. Two new saponins, (23S)-21β-O-methyl-3β,20ξ-dihydroxy-12-oxo-21,23-epoxydammar-24-ene-3-O-[α-L-rhamnopyranosyl(1→2)][β-D-glucopyranosyl(1→3)]-α-L-arabinopyranoside (4) and 23β-H-3β,20ξ-dihydroxy-19-oxo-21,23-epoxydammar-24-ene-3-O-[α-L-rhamnopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-α-L-arabinopyranoside (5), together with one lactone, 3,5-dihydroxyfuran-2(5H)-one (1), and two flavonoids, rutin (2) and kaempferol 3-O-rutinoside (3), were characterised in the aerial parts of tetraploid jiaogulan. The chemical structures of the five isolated compounds were elucidated by NMR, HR-MS spectra and chemical degradation. The five compounds were also examined and compared with the methanol extract and n-butanol soluble fraction of the jiaogulan for their inhibitory activities on lipopolysaccharide (LPS)-induced IL-1β, IL-6 and COX-2 mRNA expression in RAW 264.
2.Relationships between phyllosphere bacterial communities and plant functional traits in a neotropical forest.
Kembel SW1, O'Connor TK2, Arnold HK3, Hubbell SP4, Wright SJ5, Green JL6. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13715-20. doi: 10.1073/pnas.1216057111. Epub 2014 Sep 15.
The phyllosphere--the aerial surfaces of plants, including leaves--is a ubiquitous global habitat that harbors diverse bacterial communities. Phyllosphere bacterial communities have the potential to influence plant biogeography and ecosystem function through their influence on the fitness and function of their hosts, but the host attributes that drive community assembly in the phyllosphere are poorly understood. In this study we used high-throughput sequencing to quantify bacterial community structure on the leaves of 57 tree species in a neotropical forest in Panama. We tested for relationships between bacterial communities on tree leaves and the functional traits, taxonomy, and phylogeny of their plant hosts. Bacterial communities on tropical tree leaves were diverse; leaves from individual trees were host to more than 400 bacterial taxa. Bacterial communities in the phyllosphere were dominated by a core microbiome of taxa including Actinobacteria, Alpha-, Beta-, and Gammaproteobacteria, and Sphingobacteria.
3.The Effect of Gynostemma pentaphyllum Extract on Mouse Dermal Fibroblasts.
Lobo SN1, Qi YQ1, Liu QZ1. ISRN Dermatol. 2014 Mar 4;2014:202876. doi: 10.1155/2014/202876. eCollection 2014.
Background. The objective of this paper is to demonstrate the effect of Gynostemma pentaphyllum extract on mouse dermal fibroblasts. Recent studies have shown that this plant may possess great antioxidant properties, which can be very beneficial in combating oxidative stress. Methods. Gynostemma pentaphyllum extract was prepared and mouse dermal fibroblasts were obtained and cultured as per our laboratory protocols. Twelve samples of cells were cultured under the same conditions and both negative and positive controls were established. Induction of oxidative stress was carried out using ultraviolet C (UVC) light. Viable cell count was carried out, using microscopy. The analysis of the overall results was processed using SPSS version 16.0. Results. Statistical analysis showed strong positive correlation between the concentration of Gynostemma pentaphyllum and the mean duration of cell viability (rs = 1), with a high level of statistical significance (P < 0.
4.A new dammarane-type saponin from Gynostemma pentaphyllum induces apoptosis in A549 human lung carcinoma cells.
Xing SF1, Jang M2, Wang YR1, Piao XL3. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1754-9. doi: 10.1016/j.bmcl.2016.02.046. Epub 2016 Feb 17.
Gynostemma pentaphyllum has been widely used as a traditional herb for its antioxidant and immunostimulatory activities. We have previously reported several useful dammarane-type saponins with cytotoxicity against A549 human lung cancer cells from heat-processed G. pentaphyllum. In this study, a new dammarane-type saponin, 20(S)-2α,3β,12β-tetrahydroxydammar-3-O-β-d-glucopyranoside (namely gypenoside Jh1), was isolated from the ethanol extract of heat-processed G. pentaphyllum using column chromatography and semi-preparative HPLC. Gypenoside Jh1 exhibited strong cytotoxicity against A549 cells in a concentration-dependent manner, which was associated with apoptotic cell death characterized by morphological changes, Hoechst 33258 nuclear staining, Annexin V and propidium iodide binding and mitochondrial potentials assay. Quantitative analysis using flow cytometry also showed that the proportion of apoptotic cells was increased after gypenoside Jh1 treatment.
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