GYKI 47261 dihydrochloride - CAS 1217049-32-5
Catalog number: 1217049-32-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H17Cl3N4
Molecular Weight:
395.71
COA:
Inquire
Targets:
AMPAR
Description:
This active molecular is Non-competitiv a AMPA antagonist with IC50 value of 2.5 μM. GYKI-47261 is also a CYP2E1 inducer. GYKI-47261 showed broad spectrum of anticonvulsive and really good neuroprotective effect in vivo. AMPA and NMDA receptors have been implicated in the regulation of corticostriatal synaptic efficacy which abundantly expressed on striatal medium spiny neurons. In 2000, preclinical development for Epilepsy in Hungar was on-going, but no development was reported yet.
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Purity:
98%
Appearance:
Yellow solid
Synonyms:
4-(8-chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-yl)aniline;dihydrochloride;220445-20-5 (free base)
Solubility:
Soluble to 100 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Epilepsy; Parkinson's disease; Stroke
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
HUNSEMNKAFDVDI-UHFFFAOYSA-N
InChI:
InChI=1S/C18H15ClN4.2ClH/c1-11-10-23-17(21-11)8-13-2-5-14(19)9-16(13)18(22-23)12-3-6-15(20)7-4-12;;/h2-7,9-10H,8,20H2,1H3;2*1H
Canonical SMILES:
CC1=CN2C(=N1)CC3=C(C=C(C=C3)Cl)C(=N2)C4=CC=C(C=C4)N.Cl.Cl
Current Developer:
Originator: IVAX Pharmaceuticals UK; Nonindustrial source
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