Gyki 13324 - CAS 76123-41-6
Catalog number: 76123-41-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H18Cl2N6O6
Molecular Weight:
389.19
COA:
Inquire
Targets:
Others
Description:
GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. It can produce long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, seems to be a candidate in the clinical management of colorectal tumors.
Purity:
98%
Appearance:
Powder
Synonyms:
N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
colorectal tumor
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
UYXBAEBEXLEPKR-UHFFFAOYSA-N
InChI:
1S/C10H18Cl2N6O6/c11-1-3-13-9(21)18(16-24)6-8(20)7(19)5-14-10(22)17(15-23)4-2-12/h7-8,19-20H,1-6H2,(H,13,21)(H,14,22)
Canonical SMILES:
ClCCN(N=O)C(=O)NC[C@@H]([C@@H](CN(N=O)C(NCCCl)=O)O)O
1.Effect of a new bifunctional nitrosoureido derivative on human colorectal tumor xenografts.
Kopper L;Lapis K;Csányi E;Horváth T Anticancer Res. 1981;1(4):229-33.
The tumor inhibiting effect of a newly developed bifunctional nitrosoureido derivative (GYKI-13324) was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.
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