GW 627368X - CAS 439288-66-1
Catalog number:
B0084-313850
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H28N2O6S
Molecular Weight:
544.62
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-313850 50 mg $188 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥96%
Appearance:
A crystalline solid
Synonyms:
N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide;
4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A potent and selective competitive antagonist.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
XREWXJVMYAXCJV-UHFFFAOYSA-N
InChI:
1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
Canonical SMILES:
CCOc1c2C(=O)N(Cc2c(OCC)c2ccccc12)c1ccc(cc1)CC(=O)NS(=O)(=O)c1ccccc1
Current Developer:
GlaxoSmithKline
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Prostaglandin Receptor Products


FR-181157
(CAS: 200433-03-0)

FR-181157 is an orally active prostacyclin mimetic that shows high potency and agonist efficacy at the IP receptor.

CAS 2624-44-4 Ethamsylate

Ethamsylate
(CAS: 2624-44-4)

Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhe...

CAS 1369489-71-3 E7046

E7046
(CAS: 1369489-71-3)

E7046 is an orally bioavailable and specific type 4 prostaglandin E2 (PGE2) receptor EP antagonist (IC50= 13.5 nM) (Ki= 23.14 nM), with anti-tumor activities.

Terutroban
(CAS: 165538-40-9)

Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 indu...

GSK-345931A sodium
(CAS: 869499-38-7)

GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.

MF592
(CAS: 1064195-48-7)

MF592 is a potent and selective antagonists of the EP4 receptor. It has good functional potency and potent inhibition of PGE2 modulated TNFa release in LPS stim...

CAS 439288-66-1 GW 627368X

GW 627368X
(CAS: 439288-66-1)

GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, resp...

CAS 415903-37-6 Grapiprant (CJ-023423)

Grapiprant (CJ-023423)
(CAS: 415903-37-6)

Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic prop...

CAS 62561-03-9 (+)-Cloprostenol sodium salt

(+)-Cloprostenol sodium salt
(CAS: 62561-03-9)

(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used ...

CAS 847728-01-2 CJ-42794

CJ-42794
(CAS: 847728-01-2)

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It ...

CAS 1175526-27-8 AM-211

AM-211
(CAS: 1175526-27-8)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

CAS 223488-57-1 CP-533536

CP-533536
(CAS: 223488-57-1)

CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local b...

CAS 851204-35-8 EP1-antanoist-1

EP1-antanoist-1
(CAS: 851204-35-8)

A EP1 antagonist (pKi= 7.54) (pIC50= 8.5)

CAS 143443-90-7 Ifetroban

Ifetroban
(CAS: 143443-90-7)

Ifetroban is a selective Prostaglandin receptor and Thromboxane A2 receptor antagonist under the development of Bristol-Myers Squibb. Phase II clinical trials f...

PF-04418948
(CAS: 1078166-57-0)

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PG...

CAS 402473-54-5 ONO-AE3-208

ONO-AE3-208
(CAS: 402473-54-5)

ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, a...

CAS 892549-43-8 Mf-63

Mf-63
(CAS: 892549-43-8)

Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, r...

CAS 55028-72-3 Cloprostenol sodium

Cloprostenol sodium
(CAS: 55028-72-3)

Cloprostenol sodium is a synthetic and water-soluble aryl-oxymethyl analog of prostaglandin F2α. lt is also a potent inhibitor of rat adipose precursor differen...

PF-4217329
(CAS: 1005549-94-9)

PF-04217329 is a potent and selective EP2 receptor agonist on intraocular pressure in preclinical models of glaucoma. It is a prodrug of CP-544326. It is well t...

CAS 915191-42-3 MF498

MF498
(CAS: 915191-42-3)

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, a Gs protein-coupled receptor, with Ki of 0.7 nM. It plays important roles in ...

Chemical Structure

CAS 439288-66-1 GW 627368X

Quick Inquiry

Verification code

Featured Items