Guanfacine - CAS 29110-47-2
Catalog number: 29110-47-2
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C9H9Cl2N3O
Molecular Weight:
246.10
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hyperactivity disorder (ADHD) and hypertension. It lowers both systolic and diastolic blood pressure due to activating the central nervous system α2A norep
Publictions citing BOC Sciences Products
  • >> More
Purity:
> 95%
Appearance:
White Solid
Synonyms:
N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide BS 100 141 BS-100-141 BS100141 Estulic Guanfacine Guanfacine Hydrochloride Guanfacine Monohydrochloride Hydrochloride, Guanfacine Lon798 Monohydrochloride, Guanfacine Tenex
Solubility:
water:1.89 mg/ml
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Milligrams-Grams
Melting Point:
226 °C
Density:
1.50±0.1 g/cm3
InChIKey:
INJOMKTZOLKMBF-UHFFFAOYSA-N
InChI:
1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
Canonical SMILES:
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
1.Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation.
Kawada T1, Shimizu S2, Turner MJ2, Fukumitsu M2, Yamamoto H3, Sugimachi M2. Life Sci. 2016 Mar 15;149:72-8. doi: 10.1016/j.lfs.2016.02.051. Epub 2016 Feb 13.
AIMS: To assess the acute effects of intravenous guanfacine, an α2A-adrenergic agonist, on sympathetic outflow from the central nervous system and on sympathetic arterial pressure (AP) response.
2.Extended-release guanfacine hydrochloride in 6-17-year olds with ADHD: a randomised-withdrawal maintenance of efficacy study.
Newcorn JH1, Harpin V2, Huss M3, Lyne A4, Sikirica V5, Johnson M6, Ramos-Quiroga JA7,8, van Stralen J9, Dutray B10, Sreckovic S11, Bloomfield R4, Robertson B5. J Child Psychol Psychiatry. 2016 Feb 12. doi: 10.1111/jcpp.12492. [Epub ahead of print]
BACKGROUND: Extended-release guanfacine hydrochloride (GXR), a selective α2A-adrenergic agonist, is a nonstimulant medication for attention-deficit/hyperactivity disorder (ADHD). This phase 3, double-blind, placebo-controlled, randomised-withdrawal study evaluated the long-term maintenance of GXR efficacy in children/adolescents with ADHD.
3.Guanfacine Use in Children With Down Syndrome and Comorbid Attention-Deficit Hyperactivity Disorder (ADHD) With Disruptive Behaviors.
Capone GT1, Brecher L2, Bay M3. J Child Neurol. 2016 Mar 2. pii: 0883073816634854. [Epub ahead of print]
The purpose of this study was to characterize children with Down syndrome and attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors using the Aberrant Behavior Checklist (ABC), and to measure the treatment effects of guanfacine on maladaptive behaviors. Subjects were enrolled from a group of outpatients who visited our clinic between 2002 and 2007. Subjects (N = 23) were children with Down syndrome ages 4 to 12 years (mean 7.4 ± 4.1), who met criteria for ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The Aberrant Behavior Checklist Irritability and Hyperactivity subscales each showed a significant decrease (P < .0001) at follow-up. The mean decline on Hyperactivity was 25% (-7.8 points), and for Irritability, 25% (-3.5 points). The mean composite score also declined by 24% (-12 points). Effect size differences on Irritability were moderate, whereas differences on Hyperactivity and composite score appeared large.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Adrenergic Receptor Products


CAS 24047-25-4 Guanoxabenz

Guanoxabenz
(CAS: 24047-25-4)

Guanoxabenz, a metabolite of guanaben, is an α2 adrenergic receptor agonist.

CAS 63659-18-7 Betaxolol

Betaxolol
(CAS: 63659-18-7)

Betaxolol is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

CAS 208993-54-8 Fiduxosin

Fiduxosin
(CAS: 208993-54-8)

Fiduxosin is a potent antagonist of α1-adrenoceptor, with Ki= 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively. Fiduxosin was...

CAS 29110-48-3 Guanfacine HCl

Guanfacine HCl
(CAS: 29110-48-3)

Guanfacine HCl is the hydrochloride salt of Guanfacine. Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hype...

CAS 56392-17-7 Metoprolol Tartrate

Metoprolol Tartrate
(CAS: 56392-17-7)

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

CAS 54-80-8 Pronetalol

Pronetalol
(CAS: 54-80-8)

Pronethalol is a non-selective beta-adrenergic blocking agentused in treatment due to carcinogenic properties.

CAS 86880-51-5 ICI141292

ICI141292
(CAS: 86880-51-5)

ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertensi...

CAS 145108-58-3 Dexmedetomidine HCl

Dexmedetomidine HCl
(CAS: 145108-58-3)

Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant s...

MK-467
(CAS: 130466-38-5)

MK-467 is a peripheral Alpha2 -adrenoceptor antagonist originated by Merck & Co. It can dose-dependently attenuate the bradycardia associated with dexmedetomidi...

CAS 200050-59-5 L-771688

L-771688
(CAS: 200050-59-5)

L-771688, also known as SNAP 6383, is a new potent and highly selective α1A-adrenoceptor antagonist with 500-fold selective over α1B and α1D-adrenoceptors.

MK-0634 dihydrochloride
(CAS: 211031-81-1)

MK-0634, also called as L-796568, is an β3 adrenergic receptor agonist that was progressed into clinical studies for the treatment of obesity in the early 2000s...

Batefenterol
(CAS: 743461-65-6)

Batefenterol is a Beta 2 adrenergic receptor agonist and also a Muscarinic receptor antagonist. It shows high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic rec...

CAS 84638-81-3 ZK-90055 hydrochloride

ZK-90055 hydrochloride
(CAS: 84638-81-3)

ZK-90055, a β‐Adrenoceptor agonist, is a B-2 bronchodilator drug.

CAS 104344-23-2 Bisoprolol fumarate

Bisoprolol fumarate
(CAS: 104344-23-2)

Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.

Asenapine hydrochloride
(CAS: 1412458-61-7)

Asenapine hydrochloride, also called Org 5222 and HSDB 8061, shows high affinity for numerous receptors including 5-HT receptor and adrenergic receptor. (pKi: 5...

CAS 58020-43-2 Hoku-81

Hoku-81
(CAS: 58020-43-2)

Hoku 81 is a bronchodilator, and one of the metabolites of tulobuterol.

CAS 34381-68-5 Acebutolol hydrochloride

Acebutolol hydrochloride
(CAS: 34381-68-5)

Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

CAS 29122-68-7 Atenolol

Atenolol
(CAS: 29122-68-7)

Atenolol, with antianginal and antiarrhythmic properties, it is a cardioselective beta-adrenergic blocker and used in hypertension control.

CAS 94749-08-3 Salmeterol Xinafoate

Salmeterol Xinafoate
(CAS: 94749-08-3)

Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstru...

(RS)-Butyryltimolol

(RS)-Butyryltimolol is the racemate of Butyryltimolol which is the butyryl ester of Timolol. Timolol, in the non-selective β blocker family of medication, has b...

Chemical Structure

CAS 29110-47-2 Guanfacine

Quick Inquiry

Verification code

Featured Items