GTS-21 - CAS 156223-05-1
Catalog number:
156223-05-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H20N2O2
Molecular Weight:
308.38
COA:
Inquire
Targets:
nAChR
Description:
GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Solid powder
Synonyms:
GTS-21; GTS 21; GTS21; DMBX-A
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
Canonical SMILES:
COC1=CC=C(/C=C2C(C3=CC=CN=C3)=NCCC/2)C(OC)=C1
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related nAChR Products


CAS 1000279-69-5 A-867744

A-867744
(CAS: 1000279-69-5)

A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X....

CP-601927
(CAS: 357425-02-6)

CP-601927 is a CNS-penetrant, high affinity, and selective nicotinic acetylcholine receptor (nAChR) agonist.

CP-810123
(CAS: 439608-12-5)

CP-810123 is a novel alpha 7 nAChR agonist with potential treatment for cognitive deficits associated with psychiatric or neurological conditions including schi...

CAS 249296-44-4 Varenicline

Varenicline
(CAS: 249296-44-4)

Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and dec...

Bradanicline hydrochloride
(CAS: 1111941-90-2)

Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potentia...

CAS 134-63-4 α-Lobeline Hydrochcloride

α-Lobeline Hydrochcloride
(CAS: 134-63-4)

The hydrochloride salt form of α-Lobeline, a nicotinic receptor agonist, could be used against asphyxia and respiratory failure.

CAS 15585-43-0 RJR-2403

RJR-2403
(CAS: 15585-43-0)

At concentrations up to 1 mM, RJR-2403 does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves fo...

CAS 799279-80-4 Sofinicline

Sofinicline
(CAS: 799279-80-4)

Sofinicline is a novel nicotinic acetylcholine receptor agonist under development of Abbott Laboratories. Till now, no development was reported for Phase-II for...

CAS 550999-74-1 Encenicline, HCl salt

Encenicline, HCl salt
(CAS: 550999-74-1)

EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-ago...

CAS 501925-31-1 PNU-120596

PNU-120596
(CAS: 501925-31-1)

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

Nelonicline
(CAS: 1026134-63-3)

Nelonicline is an Alpha7 nicotinic acetylcholine receptor(nAChR) agonist and Nicotinic acetylcholine receptor agonist. It plays a key role in inflammatory proce...

CAS 15500-66-0 Pancuronium dibromide

Pancuronium dibromide
(CAS: 15500-66-0)

Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine。

CAS 55-97-0 Hexamethonium Bromide

Hexamethonium Bromide
(CAS: 55-97-0)

Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

CAS 230615-23-3 Varenicline Hydrochloride

Varenicline Hydrochloride
(CAS: 230615-23-3)

Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and dec...

CAS 541-22-0 Decamethonium Bromide

Decamethonium Bromide
(CAS: 541-22-0)

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

CAS 96946-42-8 Cisatracurium besylate

Cisatracurium besylate
(CAS: 96946-42-8)

Cisatracurium besylate is a neuromuscular blocking agent that is used in liver transplant patient with safety. Cisatracurium besylate is also an enantiomer of A...

CAS 7187-66-8 Trimethaphan

Trimethaphan
(CAS: 7187-66-8)

Trimetaphan camsilate can counteract cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and this lead to block both t...

Facinicline
(CAS: 677306-35-3)

Facinicline is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's. It was being co-developed by Roche an...

CAS 50-42-0 Adiphenine hydrochloride

Adiphenine hydrochloride
(CAS: 50-42-0)

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug.

CAS 198283-73-7 ABT-594

ABT-594
(CAS: 198283-73-7)

ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan wh...

Chemical Structure

CAS 156223-05-1 GTS-21

Quick Inquiry

Verification code

Featured Items