|Molecular Formula||C10H16N5O13P3S (free acid)|
|Molecular Weight||539.24 (free acid)|
|Structure\Application||Phosphate modified Nucleotides | Nucleotides applied on Proteins/Enzymes|
|Description||GTPγS is a stable G-protein-activating (GTP) analog. The physiological actions of GTPgammaS includestimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.|
|Purity||≥ 90 % by HPLC, contains < 10 % GDP|
|Synonyms||Guanosine-5'-(γ-thio)-triphosphate, Tetralithium salt; Guanosine-5'-(3-thio)-triphosphate; Guanosine-5'-(3-thiotriphosphate)|
ATPγS is an agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, used as a reagent in...
6-PhEt-ATP-γ-S is an analogue used to specifically interact with modified receptor proteins (chemical genetics approach).
5-Bromo-UTP is commonly used to label RNA through being incorporated into RNA for the detection with anti-5-Bromo-UTP antibodies and for the random-mutation int...
The sodium salt solution form of dGTP. dGTP is a nucleoside triphosphate used in the synthesis of DNA.
GDPβS has been found to exhibit activities as an inhibitor of G-coupled protein.
GDP - lyophilized
Guanosine 5'-diphosphate could be used to study cell signaling related to G-coupled protein receptors as well as some GTPases.