GSK864 - CAS 1816331-66-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C30H31FN6O4
Molecular Weight:
558.6
COA:
Inquire
Targets:
Isocitrate Dehydrogenase (IDH)
Description:
GSK864 is a cell penetrant, selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant with IC50 values of 8.8, 15.2 and 16.6 nM for IDH1 mutants R132C, R132H, and R132G, respectively.
Publictions citing BOC Sciences Products
  • >> More
Synonyms:
(7S)-1-[(4-fluorophenyl)methyl]-3-N-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,6-dihydropyrazolo[4,3-c]pyridine-3,7-dicarboxamide; GSK 864; GSK-864
Solubility:
DMSO: ≥ 100 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
782.9±60.0 ℃ at 760 Torr
Density:
1.37±0.1 g/cm3
InChIKey:
DUCNNEYLFOQFSW-PMERELPUSA-N
InChI:
1S/C30H31FN6O4/c1-17-12-21(13-18(2)25(17)41-4)34-27(38)24-22-15-36(28(39)23-6-5-11-33-23)16-30(3,29(32)40)26(22)37(35-24)14-19-7-9-20(31)10-8-19/h5-13,33H,14-16H2,1-4H3,(H2,32,40)(H,34,38)/t30-/m0/s1
Canonical SMILES:
CC1=CC(=CC(=C1OC)C)NC(=O)C2=NN(C3=C2CN(CC3(C)C(=O)N)C(=O)C4=CC=CN4)CC5=CC=C(C=C5)F
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Isocitrate Dehydrogenase (IDH) Products


CAS 1355326-35-0 AGI-5198

AGI-5198
(CAS: 1355326-35-0)

AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.

Enasidenib (AG-221)
(CAS: 1446502-11-9)

Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2).

CAS 6147-11-1 alpha-Mangostin

alpha-Mangostin
(CAS: 6147-11-1)

Alpha-mangostin, a prenylated xanthone derivative from Mangosteen, Garcinia mangostana L. (Clusiaceae), has shown to possess diverse pharmacological activities ...

GSK321
(CAS: 1816331-63-1)

GSK321 is a highly potent, selective inhibitor of mutant IDH1 enzymes, with IC50= 4.6 nM against R132H, 3.8 nM against R132C and 2.9 nM against R132G. GSK321 st...

Mutant IDH1-IN-2
(CAS: 1429176-69-1)

Mutant IDH1-IN-2, aslo called as SCHEMBL14831158, is an inhibitor of mutant IDH protein. It is developed for the treatment of diseases associated with such muta...

CAS 1650550-25-6 Enasidenib mesylate

Enasidenib mesylate
(CAS: 1650550-25-6)

Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes indicated for the treatment of adult patients ...

Mutant IDH1-IN-1
(CAS: 1355326-21-4)

Mutant IDH1-IN-1, a mutant IDH1 R132H inhibitor, could be used in some biological studies.

Ivosidenib
(CAS: 1448347-49-6)

Ivosidenib, also called AG-120, is an oral inhibitor that specifically inhibits a mutated form of IDH1 in the cytoplasm.

SCHEMBL14831541
(CAS: 1429180-08-4)

SCHEMBL14831541, also called as Mutant IDH1 inhibitor, is an inhibitor of mutant IDH1 which is key enzymes found in cellular metabolism.

CAS 1816331-66-4 GSK864

GSK864
(CAS: 1816331-66-4)

GSK864 is a cell penetrant, selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant with IC50 values of 8.8, 15.2 and 16.6 nM for IDH1 mutant...

CAS 1432660-47-3 AGI-6780

AGI-6780
(CAS: 1432660-47-3)

Chemical Structure

CAS 1816331-66-4 GSK864

Quick Inquiry

Verification code

Featured Items