GSK5959 - CAS 901245-65-6
Catalog number:
901245-65-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H26N4O3
Molecular Weight:
394.47
COA:
Inquire
Targets:
BRPF1
Description:
GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 value of 80 nM. It exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. It is used at 10 μM final concentration in various in vitro assays. It disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3 in vitro.
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
N-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide;GSK-5959
Solubility:
DMSO: < 7.8 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
GSK-5959 disrupts chromatin binding of BRPF1 in a cellular assay .
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
527.3±50.0 °C | Condition: Press: 760 Torr
Density:
1.263±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
LTUGYAOMCKNTGG-UHFFFAOYSA-N
InChI:
InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)
Canonical SMILES:
CN1C2=CC(=C(C=C2N(C1=O)C)N3CCCCC3)NC(=O)C4=CC=CC=C4OC
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