GSK2982772 - CAS 1622848-92-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H19N5O3
Molecular Weight:
377.4
COA:
Inquire
Targets:
RIP kinase
Description:
GSK2982772, with potential effect to treat inflammatory diseases, potently binds to RIP1 with exquisite kinase specificity. In phase 2a clinical studies for psoriasis, rheumatoid arthritis, and ulcerative colitis.
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Brife Description:
A potent and ATP competitive RIP1 inhibitor (IC50= 16 nM)
Related CAS:
1987858-31-0 (hydrate)
Synonyms:
5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide
Solubility:
DMSO: ≥100 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Density:
1.40±0.1 g/cm3
InChIKey:
LYPAFUINURXJSG-AWEZNQCLSA-N
InChI:
1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1
Canonical SMILES:
CN1C2=CC=CC=C2OCC(C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4
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Chemical Structure

CAS 1622848-92-3 GSK2982772

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