GSK256471 - CAS 1133706-08-7
Catalog number:
1133706-08-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H29N3O3S
Molecular Weight:
499.63
COA:
Inquire
Targets:
Others
Description:
This active molecular is a selective and potent NK(3) antagonist. It has a high affinity for recombinant human (pK(i) value 8.9) and native guinea pig (pK(i) value 8.4) tachykinin NK(3) receptors. In the near future, GSK256471 may be potentially very useful in the treatment of schizophrenia.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
powder
Synonyms:
N-[(S)-cyclopropyl(phenyl)methyl]-3-[[methyl(methylsulfonyl)amino]methyl]-2-phenylquinoline-4-carboxamide
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
treatment of schizophrenia
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O=C(C1=C(CN(C)S(=O)(C)=O)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@@H](C4CC4)C5=CC=CC=C5
Current Developer:
GSK
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 6197-30-4 Octocrylene

Octocrylene
(CAS: 6197-30-4)

Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics.

CAS 131-57-7 Oxybenzone

Oxybenzone
(CAS: 131-57-7)

2-Hydroxy-4-methoxybenzophenone (benzophenone-3) is commonly employed as broad-band UV-filter in sunscreen cosmetic products. It protects skin from the deleteri...

GSK-1440115
(CAS: 1003878-16-7)

GSK-1440115 is an orally active urotensin II receptor antagonist. It is used for the treatment of asthma.

CAS 57-66-9 Probenecid

Probenecid
(CAS: 57-66-9)

Probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. It is able to prevent the efflux of calcium-sensitive fluor...

CAS 53963-43-2 Ginsenoside F1

Ginsenoside F1
(CAS: 53963-43-2)

Ginsenoside F1, a metabolite of ginsenoside Rg1, which is used as an aldose reductase inhibitor and my exert anti-inflammatory and immunomodulatory activity.

CAS 1334719-95-7 Q203

Q203
(CAS: 1334719-95-7)

Q203, also known as IAP6, was active against the reference strain M. tuberculosis H37Rv at a minimum concentration required to inhibit the growth of 50% of orga...

CAS 24316-19-6 Cephalotaxlen

Cephalotaxlen
(CAS: 24316-19-6)

Antiviral and antitumor agent.

CVT-3369
(CAS: 172430-48-7)

CVT-3369, a piperazineacetic acid derivative, is probably effective in some of biological studies.

CAS 1018675-35-8 CVT-12012

CVT-12012
(CAS: 1018675-35-8)

CVT-12012 is a bio-active chemical compound and is highly potent in a human cell-based (HEPG2) SCD assay with IC50 value of 6nM.

CP 46665
(CAS: 72618-10-1)

CP 46665 is Immunomodulator. But it is lack of therapeutic activity in rodent tumors and human non-seminomatous germ cell tumors growing in nude mice.

CAS 478336-92-4 ISO-1

ISO-1
(CAS: 478336-92-4)

ISO-1 is an inhibitor of the dopachrome tautomerase activity of MIF. It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and impr...

CAS 137071-32-0 Pimecrolimus

Pimecrolimus
(CAS: 137071-32-0)

Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.

CAS 1146963-51-0 J 147

J 147
(CAS: 1146963-51-0)

J 147, under the IUPAC name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide, a phenyl hydrazide compound that has been...

CAS 1421227-53-3 WS6

WS6
(CAS: 1421227-53-3)

WS6 induces R7T1 cell proliferation with EC50 of 0.28 μM, and promotes β cell proliferation in rodent and human primary islets.

CAS 162784-72-7 7-Epi-10-oxo-docetaxel

7-Epi-10-oxo-docetaxel
(CAS: 162784-72-7)

Docetaxel Impurity

CAS 405060-95-9 Salubrinal

Salubrinal
(CAS: 405060-95-9)

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.

CAS 37893-02-0 Flubenzimine

Flubenzimine
(CAS: 37893-02-0)

Flubenzimine is a synthetic anthelmintic chemical.

CAS 27314-97-2 Tirapazamine

Tirapazamine
(CAS: 27314-97-2)

Tirapazamine is a benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free rad...

CAS 786643-20-7 D149 Dye

D149 Dye
(CAS: 786643-20-7)

D149 Dye is an organic dye for highly efficient solid-state dye-sensitized solar cells.

Gepotidacin S enantiomer

Gepotidacin S enantiomer is an S enantionmer of gepotidacin which is a potent Type II DNA topoisomerase inhibitor and appears as a novel antibacterial drug cand...

Quick Inquiry

Verification code

Featured Items