GSK2245035 - CAS 1207629-49-9
Catalog number: 1207629-49-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H34N6O2
Molecular Weight:
390.52
COA:
Inquire
Targets:
Toll-like Receptor (TLR)
Description:
This active molecular is a selective TLR7 (Toll-like receptor 7) agonist with preferential Type-1 IFN-stimulating properties which is under development of GlaxoSmithKline. GSK2245035 displays potent IFNα inducing potency and IFNα/TNFα selectivity. In Aug 2015, GlaxoSmithKline completed a phase II follow-up trial for Allergic asthma and Allergic rhinitis in Canada. In Jul 2016, GlaxoSmithKline planed a phase II trial for Allergic asthma in Germany (Intranasal).
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Purity:
98%
Appearance:
Powder
Synonyms:
(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one;1325212-97-2 (maleate salt)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Allergic asthma; Allergic rhinitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O=C1NC2=C(N)N=C(O[C@@H](C)CCC)N=C2N1CCCCCN3CCCCC3
Current Developer:
Originator GlaxoSmithKline
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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