GSK2193874 - CAS 1336960-13-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C37H38BrF3N4O
Molecular Weight:
691.62
COA:
Inquire
Targets:
TRP Channel
Description:
GSK2193874 is a potent, orally active and specific antagonist of TRPV4 ion channels (IC50 values= 2 and 40 nM for rat and human receptors, respectively). GSK2193874 is selective over a panel of ~200 human receptors, channels and enzymes.
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Brife Description:
A potent, selective antagonist of TRPV4 ion channels (IC50 = 50 nM)
Synonyms:
7-bromo-N-(1-phenylcyclopropyl)-3-[(4-piperidin-1-ylpiperidin-1-yl)methyl]-2-[3-(trifluoromethyl)phenyl]quinoline-4-carboxamide; GSK2193874; GSK 2193874; GSK-2193874
Solubility:
DMSO: ≥ 100 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
737.8±60.0 ℃ at 760 Torr
Density:
1.43±0.1 g/cm3
InChIKey:
UIVOZBSCHXCGPS-UHFFFAOYSA-N
InChI:
1S/C37H38BrF3N4O/c38-28-12-13-30-32(23-28)42-34(25-8-7-11-27(22-25)37(39,40)41)31(24-44-20-14-29(15-21-44)45-18-5-2-6-19-45)33(30)35(46)43-36(16-17-36)26-9-3-1-4-10-26/h1,3-4,7-13,22-23,29H,2,5-6,14-21,24H2,(H,43,46)
Canonical SMILES:
C1CCN(CC1)C2CCN(CC2)CC3=C(N=C4C=C(C=CC4=C3C(=O)NC5(CC5)C6=CC=CC=C6)Br)C7=CC(=CC=C7)C(F)(F)F
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CAS 1336960-13-4 GSK2193874

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