|Targets||Sphingosine-1-phosphate receptor 1(S1PR1)|
|Description||GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. It showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3 upon phosphorylation. It has good oral bioavailability. It was selected as a candidate for further clinical on the basis of the favorable in vitro ADME and in vivo PK/PD properties as well as broad toxicology evaluations.|
|Solubility||10 mM in DMSO|
|Application||GSK1842799 was selected as a candidate for further clinical.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
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