|Description||GSK180736A is a selective GRK2 inhibitor with an IC50 of 0.77 μM. It is also a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM).|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
Y-33075 dihydrochloride is a selective ROCK inhibitor (IC50= 3.6nM) derived from Y-27632, and is more potent than Y-27632.
Y-33075, also called as SNJ-1656, a well-characterized ROCK inhibitor, inhibits more potently ROCK by about 30 times than Y-27632, a common specific ROCK inhibi...
Verosudil is a selective Rho-kinase inhibitor originated by Aerie Pharmaceuticals. In Jun 2013, Phase-II for Ocular hypertension in USA was discontinued. In Sep...
KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nm, respectively. Phase 2.
ZINC00881524 is a specific ROCK inhibitor.
Chroman 1, a chroman-based compound, is an effective ROCK II inhibitor which could probably influence the cell motility involved in sorts of disorders.
K-115, also called as Ripasudil or Glanatec, a selective ROCK inhibitor (IC50 =31 nM), is a promising emerging antiglaucoma drug, and was thus approved by the J...
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
Fasudil HCl, a 5-isoquinolinesulfonamide derivative, is a highly selective Rho-associated protein kinase inhibitor that might have a rate in romoting the recove...
(S)-H-1152 dihydrochloride is a Rho-kinase inhibitor and cell permeable inhibitor of ROCK (Ki = 1.6 nM).
C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 µM, respectively) and is widely used as a ROCK inhibitor.
OXA 06 dihydrochloride is a ROCK inhibitor with IC50 value of 10 nM. It can suppress pMYPT1 and pCofilin levels in non-small cell lung carcinoma cell lines.
SB 772077B dihydrochloride
SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 ~ 5.6 nM at recombinant human ROCK1 and 2) exhibiting potent vasodilator activity. SB 7...
H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein R...
SR 3677 is an effective ROCK inhibitor, espectially against ROCK II and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueo...
SAR-407899 is a potent, ATP-competitive ROCK inhibitor. It is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and...
Hydroxyfasudil, formed through the metabolism action of Fasudil, could be useful in improving the symptoms of pulmonary hypertension for playing the role as an ...
Glycyl-H 1152 dihydrochloride
Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride with an improved selectivity for ROCKII (IC50 = 0.0118, 2.35...
6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine is potent and highly selective ROCK inhibitor. Its IC50 v...