|Description||GSK180736A is a selective GRK2 inhibitor with an IC50 of 0.77 μM. It is also a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC50 = 100 nM).|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
Chroman 1, a chroman-based compound, is an effective ROCK II inhibitor which could probably influence the cell motility involved in sorts of disorders.
KD025 is an orally available, and selective ROCK2 inhibitor with IC50 and Ki of 60 nM and 41 nm, respectively. Phase 2.
Hydroxyfasudil, formed through the metabolism action of Fasudil, could be useful in improving the symptoms of pulmonary hypertension for playing the role as an ...
SAR-407899 hydrochloride is the hydrochloride form of SAR-407899, which is a potent, ATP-competitive ROCK inhibitor. It has good antihypertensive activity.
Verosudil is a selective Rho-kinase inhibitor originated by Aerie Pharmaceuticals. In Jun 2013, Phase-II for Ocular hypertension in USA was discontinued. In Sep...
(S)-H-1152 dihydrochloride is a Rho-kinase inhibitor and cell permeable inhibitor of ROCK (Ki = 1.6 nM).
Y-33075, also called as SNJ-1656, a well-characterized ROCK inhibitor, inhibits more potently ROCK by about 30 times than Y-27632, a common specific ROCK inhibi...
Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hyperte...
Y-27632 2HCl inhibits ROCK-II while displaying little activity against PKC, cAMP-dependent protein kinase and myosin light-chain kinase (MLCK) with Ki of 26 μM,...
GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
Y-33075 dihydrochloride is a selective ROCK inhibitor (IC50= 3.6nM) derived from Y-27632, and is more potent than Y-27632.
H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein R...
6-Chloro-n4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine is potent and highly selective ROCK inhibitor. Its IC50 v...
SR 3677 is an effective ROCK inhibitor, espectially against ROCK II and it could block the phosphorylation ofmyosin light chain and promote the outflow of aqueo...
GSK180736A is a selective GRK2 inhibitor with an IC50 of 0.77 μM. It is also a weak inhibitor of PKA with an IC50 of 30 μM, but highly potent against ROCK1 (IC5...
K-115, also called as Ripasudil or Glanatec, a selective ROCK inhibitor (IC50 =31 nM), is a promising emerging antiglaucoma drug, and was thus approved by the J...
Fasudil is a potent and selective Rho-kinase (ROCK) inhibitor and vasodilator. ROCK is an enzyme that participates in vasoconstriction and vascular remodeling. ...