GSK1016790A - CAS 942206-85-1
Catalog number: B0084-382782
Category: Inhibitor
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TRP Channel
GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone. It elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells with EC50 values of 18 and 2.1 nM, respectively. It also evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM, which is 300 fold more potent than 4a-PDD. It was developed by GlaxoSmithKline.
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Catalog Number Size Price Stock Quantity
B0084-382782 100 mg $748 In stock
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>98 %
White Solid
DMSO ≥ 33 mg/mL
-20°C Freezer
GSK1016790A regulats urinary bladder activity and endothelial control of vascular tone.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
1.426±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Tor
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GSK1016790A was developed by GlaxoSmithKline.
1.NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2.
Addison MP1, Singh TU2, Parida S1, Choudhury S1, Kasa JK1, Sukumaran SV1, Darzi SA1, Kandasamy K1, Singh V1, Kumar D1, Mishra SK1. Pharmacol Rep. 2016 Jun;68(3):620-6. doi: 10.1016/j.pharep.2016.01.003. Epub 2016 Jan 19.
BACKGROUND: The aim of the present study was to observe the concomitant activation of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) pathways by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery and explore the mechanism by which NO synthase inhibition attenuates EDHF-mediated relaxation in endothelium-intact rat pulmonary artery.
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CAS 942206-85-1 GSK1016790A

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