|Description||GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone. It elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells with EC50 values of 18 and 2.1 nM, respectively. It also evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM, which is 300 fold more potent than 4a-PDD. It was developed by GlaxoSmithKline.|
|B0084-382782||100 mg||$748||In stock|
|Solubility||DMSO ≥ 33 mg/mL|
|Application||GSK1016790A regulats urinary bladder activity and endothelial control of vascular tone.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Density||1.426±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Tor|
|Current Developer||GSK1016790A was developed by GlaxoSmithKline.|
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