|Description||GSK'872 is aRIPK3inhibitor, which binds RIP3 kinase domain with high affinity (IC50=1.8 nM), and is approximately >1,000-fold selective over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM. Besides, GSK'872 inhibits kinase activity (IC50=1.3 nM).|
|Brife Description||An inhibitor of receptor interacting protein kinase-3 (RIP3)|
|Solubility||DMSO: ≥ 150 mg/mL|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||625.7±55.0 ℃ at 760 Torr|
WEHI-345, a pyrazolo-pyridine derivative, is a RIPK2 inhibitor and has been found to influence the production of inflammatory cytokine. IC50: 0.13 μM.
GSK'872 is aRIPK3inhibitor, which binds RIP3 kinase domain with high affinity (IC50=1.8 nM), and is approximately >1,000-fold selective over 300 kinases in a fl...
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) (IC50= 13 nM), and efficiently reduced tumor ...
GSK2982772, with potential effect to treat inflammatory diseases, potently binds to RIP1 with exquisite kinase specificity. In phase 2a clinical studies for pso...
GSK481 is a potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of Ser166 autophosphoryl...
OD-36, a macrocycle compound, has been found to be a RIPK2 inhibitor that could decrease cellular infiltration induced by MDP in neutrophils and lymphocytes. IC...