GSK-7975A - CAS 1253186-56-9
Catalog number: 1253186-56-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H12F5N3O2
Molecular Weight:
397.31
COA:
Inquire
Targets:
Others
Description:
This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activation of Ca(2+) currents after Ca(2+) release in mouse and human pancreatic acinar cells. GSK-7975A may be used for the treatment of pancreatitis in the future.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
SCHEMBL705705; AOB4124; CPYTVBALBFSXSH-UHFFFAOYSA-N;2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
pancreatitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
CPYTVBALBFSXSH-UHFFFAOYSA-N
InChI:
InChI=1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28)
Canonical SMILES:
C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
Current Developer:
GSK
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 434-05-9 Methenolone acetate

Methenolone acetate
(CAS: 434-05-9)

Metenolone enanthate,is a dihydrotestosterone based anabolic steroid with weak androgenic properties.

CAS 60-70-8 Veratramine

Veratramine
(CAS: 60-70-8)

Veratramine is useful as a signal transduction inhibitor for treating tumors.

CAS 1953-02-2 Tiopronin

Tiopronin
(CAS: 1953-02-2)

Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretio...

PD-116779
(CAS: 102674-89-5)

PD-116779 is a novle antitumor antibiotic belonging the benz[a]anthraquinone class.

CAS 119-41-5 Efloxate

Efloxate
(CAS: 119-41-5)

Efloxate, a flavone derivative, could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator.

JNJ-42259152
(CAS: 1301167-87-2)

This molecular is a phosphodiesterase 10A PET tracer. Related studies show that PDE10A activity can be reliably quantified and simplified using a reference tiss...

CAS 14087-31-1 Gaxilose

Gaxilose
(CAS: 14087-31-1)

Gaxilose is a synthetic disaccharide and a substrate of intestinal lactase. It can be applicated in a new noninvasive diagnostic test based on urine or serum me...

GLPG-1690
(CAS: 1628260-79-6)

GLPG-1690, an imidazopyridine derivative, has been found to be a ENPP2 protein inhibitor that could probably be effective as an anti-inflammatory agent and is u...

CAS 1492-02-0 Glybuzole

Glybuzole
(CAS: 1492-02-0)

Glybuzole, a benzenesulfonamide derivative, has been found to have antihyperglycemic through stimulating the release of insulin.

CAS 129497-78-5 Verteporfin

Verteporfin
(CAS: 129497-78-5)

Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin. It is used as a photosensitizer for photodynamic therapy to eliminate a...

CAS 1021-11-0 Guanoxyfen sulfate

Guanoxyfen sulfate
(CAS: 1021-11-0)

Guanoxyfen sulfate is an inhibitor of vasoconstrictor responses to sympathetic nerve stimulation. It could potentiate the actions of adrenaline and noradrenalin...

CAS 112887-68-0 Raltitrexed

Raltitrexed
(CAS: 112887-68-0)

Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

CP-67804
(CAS: 103978-08-1)

CP-67804 enhances topoisomerase II-mediated DNA cleavage. It represent a novel class of topoisomerase II-targeted drugs which have potential as antineoplastic a...

CHEMBL2426474
(CAS: 1418741-86-2)

CHEMBL2426474, also called as UNC1079, the piperidine analog of UNC1021 that has binding affinity to L3MBTL3 in human G401 cells by Western blot based pulldown ...

CAS 130693-82-2 Dorzolamide hydrochloride

Dorzolamide hydrochloride
(CAS: 130693-82-2)

Dorzolamide hydrochloride is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. Dorzolamide hydrochlor...

CAS 195514-63-7 AP1903

AP1903
(CAS: 195514-63-7)

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which...

CAS 1464-42-2 Selenomethionine

Selenomethionine
(CAS: 1464-42-2)

Selenomethionine is an essential nutrient that may have a role in other biologically active compounds, especially vitamin E and the enzyme formic dehydrogenase.

CAS 3262-64-4 S-Propargyl-Cysteine

S-Propargyl-Cysteine
(CAS: 3262-64-4)

S-Propargyl-cysteine (SPRC) is a modulator of endogenous hydrogen disulfide (H2S) with antioxidant activity. SPRC is potentially used for the treatment of Alzhe...

CAS 1015474-32-4 CC122

CC122
(CAS: 1015474-32-4)

CC122 is a novel agent for DLBCL. It is an orally available pleiotropic pathway modulator. It has antitumor and immunomodulatory activity. It is used for the tr...

CAS 234113-94-1 GMC 61-39

GMC 61-39
(CAS: 234113-94-1)

GMC 61-39 is a clozapine-like atypical antipsychotic.

Quick Inquiry

Verification code

Featured Items