GSK-461364 - CAS 929095-18-1
Catalog number: 929095-18-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
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Targets:
Polo-like Kinase (PLK)
Description:
GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
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Appearance:
white solid powder
Synonyms:
GSK-461364
MSDS:
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Current Developer:
GSK
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Chemical Structure

CAS 929095-18-1 GSK-461364

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