GSK 461364 analogue I - CAS 929095-23-8
Category: Inhibitor
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Molecular Formula:
C26H27ClN4O3S
Molecular Weight:
511.04
COA:
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Targets:
Polo-like Kinase (PLK)
Description:
GSK 461364 analogue I is a potent polo-like kinase (PLK) inhibitor with selectivity for PLK1 (IC50: 2 nM) over PLK3 (IC50: 630 nM).
Brife Description:
PLK inhibitor
Purity:
99%
Synonyms:
GSK 461364 analogue I; GSK461364 analogue I; GSK-461364 analogue I; GSK579289A; GSK 579289A; GSK-579289A. Compound 25 [PMID 19237286]; 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-(1-methylpiperidin-4-yl)oxybenzimidazol-1-yl]thiophene-2-carboxamide
MSDS:
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InChIKey:
GILNGUYOGYOZMP-MRXNPFEDSA-N
InChI:
InChI=1S/C26H27ClN4O3S/c1-16(19-5-3-4-6-20(19)27)33-23-14-24(35-25(23)26(28)32)31-15-29-21-8-7-18(13-22(21)31)34-17-9-11-30(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,28,32)/t16-/m1/s1
Canonical SMILES:
CC(C1=CC=CC=C1Cl)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)OC5CCN(CC5)C)C(=O)N
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CAS 929095-23-8 GSK 461364 analogue I

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