GSK-1014802 hydrochloride - CAS 934240-31-0
Catalog number:
934240-31-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H20ClFN2O2
Molecular Weight:
350.82
COA:
Inquire
Targets:
Sodium Channel
Description:
GSK-1014802 hydrochloride is the hydrochloride form of GSK-1014802, which is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It acts as a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. It received orphan-drug designation from the US Food and Drug Administration in July 2013. It was developed by Convergence Pharmaceuticals. It is currently in phase II studies in bipolar depression.
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Purity:
>98%
Appearance:
White to off-white Solid
Synonyms:
(2S,5R)-5-(4-((2-Fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide hydrochloride;(5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-L-prolinamide hydrochloride CNV1014802 hydrochloride;CNV-1014802 hydrochloride;Raxatrigine hydrochloride
Solubility:
DMSO: ≥ 31 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
GSK-1014802 hydrochloride is a novel analgesic for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia. It received orphan-drug designation from the US Food and Drug Administration in July 2013.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
InChIKey:
HEPUBAGOKRIZEO-PPPUBMIESA-N
InChI:
InChI=1S/C18H19FN2O2.ClH/c19-15-4-2-1-3-13(15)11-23-14-7-5-12(6-8-14)16-9-10-17(21-16)18(20)22;/h1-8,16-17,21H,9-11H2,(H2,20,22);1H/t16-,17+;/m1./s1
Canonical SMILES:
C1CC(NC1C2=CC=C(C=C2)OCC3=CC=CC=C3F)C(=O)N.Cl
Current Developer:
GSK-1014802 hydrochloride was developed by Convergence Pharmaceuticals. It is currently in phase II studies in bipolar depression.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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