Granisetron HCl - CAS 107007-99-8
Catalog number:
107007-99-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H24N4O.HCl
Molecular Weight:
348.87
COA:
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Targets:
5-HT Receptor
Description:
Granisetron HCl is a serotonin 5-HT3 receptor antagonist.
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Purity:
>98%
Synonyms:
N/A
MSDS:
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1.Randomized phase III trial of APF530 versus palonosetron in the prevention of chemotherapy-induced nausea and vomiting in a subset of patients with breast cancer receiving moderately or highly emetogenic chemotherapy.
Boccia R1, O'Boyle E2, Cooper W3. BMC Cancer. 2016 Feb 26;16(1):166. doi: 10.1186/s12885-016-2186-4.
BACKGROUND: APF530 provides controlled, sustained-release granisetron for preventing acute (0-24 h) and delayed (24-120 h) chemotherapy-induced nausea and vomiting (CINV). In a phase III trial, APF530 was noninferior to palonosetron in preventing acute CINV following single-dose moderately (MEC) or highly emetogenic chemotherapy (HEC) and delayed CINV in MEC (MEC and HEC defined by Hesketh criteria). This exploratory subanalysis was conducted in the breast cancer subpopulation.
2.Comparison of the Control of Nausea and Vomiting among Several Moderately Emetic-Risk Chemotherapy Regimens.
Iihara H1, Ishihara M1, Fujii H1, Yoshimi C1, Yamada M1, Suzuki A1, Yamaguchi K2, Futamura M2, Yoshida K2, Itoh Y1. J Cancer. 2016 Mar 18;7(5):569-75. doi: 10.7150/jca.13637. eCollection 2016.
BACKGROUND: Different antiemetic medications with or without aprepitant are recommended for moderately emetic-risk chemotherapy (MEC) depending on the emetic potential of chemotherapy agents, although the criterion for the use of aprepitant is still unclear. The present study was designed to compare the control of chemotherapy-induced nausea and vomiting (CINV) among several MEC regimens used in the outpatient chemotherapy setting.
3.APF530 (Granisetron injection extended-release) in a three-drug regimen for delayed CINV in highly emetogenic chemotherapy.
Schnadig ID1, Agajanian R2, Dakhil C3, Gabrail NY4, Smith RE Jr5, Taylor C6, Wilks ST7, Schwartzberg LS8, Cooper W9, Mosier MC10, Payne JY11, Klepper MJ12, Vacirca JL13. Future Oncol. 2016 Mar 21. [Epub ahead of print]
AIM: APF530, extended-release granisetron, provides sustained release for ≥5 days for acute- and delayed-phase chemotherapy-induced nausea and vomiting (CINV). We compared efficacy and safety of APF530 versus ondansetron for delayed CINV after highly emetogenic chemotherapy (HEC), following a guideline-recommended three-drug regimen.
4.Hydrophilic interaction liquid chromatography in analysis of granisetron HCl and its related substances. Retention mechanisms and method development.
Maksić J1, Tumpa A2, Stajić A2, Jovanović M2, Rakić T2, Jančić-Stojanović B3. J Pharm Biomed Anal. 2016 May 10;123:93-103. doi: 10.1016/j.jpba.2016.02.010. Epub 2016 Feb 10.
In this paper separation of granisetron and its two related substances in HILIC mode is presented. Separation was done on silica column derivatized with sulfoalkylbetaine groups (ZIC-HILIC). Firstly, retention mechanisms were assessed whereby retention factors of substances were followed in wide range of acetonitrile content (80-97%), at constant concentration of aqueous buffer (10mM) as well as at constant pH value of 3.0. Further, in order to developed optimal HILIC method, Design of Experiments (DoE) methodology was applied. For optimization full factorial design 3(2) was employed. Influence of acetonitrile content and ammonium acetate concentration were investigated while pH of the water phase was kept at 3.3. Adequacy of obtained mathematical models was confirmed by ANOVA. Optimization goals (α>1.15 and minimal run time) were accomplished with 94.7% of acetonitrile in mobile phase and 70mM of ammonium acetate in water phase. Optimal point was in the middle of defined Design Space.
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CAS 107007-99-8 Granisetron HCl

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