GRA Ex-25 - CAS 307983-31-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H36F3N3O5
Molecular Weight:
563.61
COA:
Inquire
Targets:
Glucagon Receptor
Description:
GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. GCGR has evolved as an attractive therapeutic target for the treatment of type II diabetes mellitus.
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Appearance:
Solid powder
Synonyms:
3-(4-((1-(4-(tert-butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid; GRA Ex-25; GRA Ex 25; GRA Ex25; GRAEx-25; GRAEx 25; GRAEx25.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
726.3±60.0 °C at 760 Torr
Melting Point:
152-154 °C
Density:
1.28±0.1 g/cm3
InChIKey:
BZXMLCVDKDXRQY-LOSWNTGBSA-N
InChI:
1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)/t21?,23-
Canonical SMILES:
C[C@](C1CC[C@H](N(C(NC2C=CC(OC(F)(F)F)=CC=2)=O)CC2C=CC(C(NCCC(O)=O)=O)=CC=2)CC1)(C)C
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Chemical Structure

CAS 307983-31-9 GRA Ex-25

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