GNF179 Metabolite - CAS 1310455-86-7
Catalog number: 1310455-86-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.
Publictions citing BOC Sciences Products
  • >> More
GNF 179 Metabolite; GNF-179 Metabolite
1.Divergent behavior of hydrogen sulfide pools and of the sulfur metabolite lanthionine, a novel uremic toxin, in dialysis patients.
Perna AF1, Di Nunzio A2, Amoresano A3, Pane F3, Fontanarosa C3, Piero P3, Vigorito C4, Cirillo G2, Zacchia M2, Trepiccione F2, Ingrosso D4. Biochimie. 2016 Apr 26. pii: S0300-9084(16)30071-2. doi: 10.1016/j.biochi.2016.04.018. [Epub ahead of print]
Dialysis patients display a high cardiovascular mortality, the causes of which are still not completely explained, but are related to uremic toxicity. Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine β-synthase and cystathionine γ-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production. Hydrogen sulfide is involved in the modulation of multiple pathophysiological responses. In uremia, we have demonstrated low plasma total hydrogen sulfide levels, due to reduced cystathionine γ-lyase expression. Plasma hydrogen sulfide levels were measured in hemodialysis patients and healthy controls with three different techniques in comparison, allowing to discern the different pools of this gas. The protein-bound (the one thought to be the most active) and acid-labile forms are significantly decreased, while homolanthionine, but especially lanthionine, accumulate in the blood of uremic patients.
2.Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.
Tian X1, Gao Y1, Xu Z2, Lian S3, Ma Y3, Guo X1, Hu P1, Li Z1, Huang C1. Biofactors. 2016 Apr 30. doi: 10.1002/biof.1291. [Epub ahead of print]
Mangiferin (MGF), a glucoside of xanthone existing in phytomedicines and food, is increasingly attracting attention on diabetes treatment, while the underlying mechanism leading to its low oral bioavailability is unclear. Norathyriol (NTR), an active metabolite with hypoglycemic activity and its exposure after MGF dosing remains unclear. Hence, a rapid and sensitive LC-MS/MS method was established and validated to determine MGF and NTR and applied in the PK study in rats. Correspondingly, the in vitro experiments on temperature-dependent uptake, and MGF metabolism in hepatocyte and enterobacteria samples were performed. Results revealed that hepatic first-pass effect slightly contributed to the poor bioavailability of MGF, based on the MGF exposure in portal vein plasma was nearly similar to that in systemic plasma, and the MGF accumulation in the liver was limited, so was that of NTR. Correspondingly, the in vitro study revealed the MGF uptake was mainly dependent on poor passive transport, possibly leading to its limited hepatic metabolism and accumulation.
3.The Molting Biomarker Metabolite N-acetylglucosamino-1,5-lactone in Female Urine of the Helmet Crab Telmessus cheiragonus.
Yano H1, Kamio M2, Nagai H1. Biol Bull. 2016 Apr;230(2):143-151.
N-acetylglucosamino-1,5-lactone (NAGL) is a molting biomarker in the blue crab Callinectes sapidus The concentration of this compound in urine is highest at the premolt stage. Since sexually mature premolt females release sex pheromone in their urine, NAGL is a candidate sex pheromone molecule in C. sapidus This compound has not been reported in other species. In the present study, we quantified the concentration of NAGL in the urine of the helmet crab Telmessus cheiragonus, using nuclear magnetic resonance spectroscopy, and found that the concentration increases toward the day of molting and decreases after molting. However, the total amount of NAGL collected from individual animals was greatest two to five days after molting, because the amount of urine collected was the lowest at the premolt stage, and it increased after molting. The highest median concentration of NAGL in T. cheiragonas was 29 μmol l-1, which is 75% of the highest concentration reported in C.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products

CAS 134-62-3 N,N-Diethyl-3-methylbenzamide

(CAS: 134-62-3)

N,N-Diethyl-3-methylbenzamide, a benzamide derivative, could be a significant additive in vermifuge.

CAS 31430-15-6 Flubendazole

(CAS: 31430-15-6)

Flubendazole is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N...

CAS 52645-53-1 Permethrin

(CAS: 52645-53-1)

Permethrin is a synthetic pyrethroid insectide, affecting neuron membranes by prolonging sodium channel activation.

CAS 69004-03-1 Toltrazuril

(CAS: 69004-03-1)

Toltrazuril is a coccidiostat.

CAS 97-23-4 Dichlorophen

(CAS: 97-23-4)

Dichlorophen is an anticestodal agent.

CAS 25514-31-2 Bruceine A

Bruceine A
(CAS: 25514-31-2)

Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazen...

CAS 185055-67-8 Ferroquine

(CAS: 185055-67-8)

Ferroquine, a ferrocene-based analogue, is an ingenious antimalarial agent potentially for the treatment of malaria.

CAS 31431-39-7 Mebendazole

(CAS: 31431-39-7)

Benzimidazole antihelmintic. Tubulin-disrupting drug. Antitumour activity in vitro and in vivo. Inhibits growth and induces apoptosis.

CAS 69004-04-2 Toltrazuril sulfone

Toltrazuril sulfone
(CAS: 69004-04-2)

Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites. It, sold by the Bayer Corporation under the trade name Marquis, is a drug curre...

CAS 1010411-21-8 GSK369796 Dihydrochloride

GSK369796 Dihydrochloride
(CAS: 1010411-21-8)

SK369796, also known as N-tert-butylisoquine, shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 str...

CAS 73360-56-2 Niclosamide monohydrate

Niclosamide monohydrate
(CAS: 73360-56-2)

Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication. It inhibits the TNF-induced NF-κB reporter activity...

CAS 58066-85-6 Miltefosine

(CAS: 58066-85-6)

Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effect...

CAS 133413-70-4 PF 1022A

PF 1022A
(CAS: 133413-70-4)

The cyclic depsipeptide PF1022A showed very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. In vitro, PF1022A wa...

CAS 22204-24-6 Pyrantel pamoate

Pyrantel pamoate
(CAS: 22204-24-6)

Pyrantel pamoate is used as a deworming agent in domesticated animals such as horses, hamsters, sheep, pigs, cats, and dogs. It is a combination of pyrantel and...

CAS 2277-92-1 Oxyclozanide

(CAS: 2277-92-1)

Oxyclozanide is a salicylanilide anthelmintic used in the treatment and control of Fascioliasis in ruminants mainly domestic animals like Cattle, Sheep and Goat...

CAS 3380-34-5 Triclosan

(CAS: 3380-34-5)

Triclosan is an antimicrobial agents found in many soaps and detergents, binds to bacterial ENR enzyme.

CAS 188343-77-3 MBP146-78

(CAS: 188343-77-3)


CAS 68813-55-8 Oxantel Pamoate

Oxantel Pamoate
(CAS: 68813-55-8)

Oxantel Pamoate is used as an anthelmintic. It has typically been used human and animal use as a standard treatment for intestinal worms. lt may be used as a fu...

CAS 51773-92-3 Mefloquine Hydrochloride

Mefloquine Hydrochloride
(CAS: 51773-92-3)

Mefloquine HCl is a blood schizonticide by inhibiting hemozoin formation, used as an antimalarial drug.

CAS 148477-71-8 Spirodiclofen

(CAS: 148477-71-8)

Spirodiclofen, a tetronic acid derivative, is a broad spectrum acaricide.

Chemical Structure

CAS 1310455-86-7 GNF179 Metabolite

Quick Inquiry

Verification code

Featured Items