GNF179 - CAS 1261114-01-5
Catalog number:
1261114-01-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H23ClFN5O
Molecular Weight:
427.9
COA:
Inquire
Targets:
Antiparasitic
Description:
GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.
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Purity:
>98%
Synonyms:
GNF 179; GNF-179
MSDS:
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CAS 1261114-01-5 GNF179

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