GNF 5837 - CAS 1033769-28-6
Catalog number:
1033769-28-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
Trk Receptor
Publictions citing BOC Sciences Products
  • >> More
MSDS:
Inquire
1.Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
Albaugh P1, Fan Y1, Mi Y1, Sun F1, Adrian F1, Li N1, Jia Y1, Sarkisova Y1, Kreusch A1, Hood T1, Lu M1, Liu G1, Huang S1, Liu Z1, Loren J1, Tuntland T1, Karanewsky DS1, Seidel HM1, Molteni V1. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5. doi: 10.1021/ml200261d. eCollection 2012.
Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating evidence points to their role in malignant transformations, chemotaxis, metastasis, and survival signaling and may contribute to the pathogenesis of a variety of tumors of both neural and non-neural origin. By screening the GNF kinase collection, a series of novel oxindole inhibitors of TRKs were identified. Optimization led to the identification of GNF-5837 (22), a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. The properties of 22 make it a good tool for the elucidation of TRK biology in cancer and other nononcology indications.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Trk Receptor Products


CAS 219766-25-3 ANA-12

ANA-12
(CAS: 219766-25-3)

ANA-12 is a selective TrkB antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and T...

GNE-8525
(CAS: 1196546-33-4)

This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor effica...

CAS 1802220-02-5 TPX-0005

TPX-0005
(CAS: 1802220-02-5)

TPX-0005 is an orally available and potent ATP-competitive inhibitor of ALK/ROS1/TRK (IC50= 5.3 nM for SRC, IC50= 1.01 nM, 1.26 nM and 1.08 nM for mutant ALKs i...

Belizatinib
(CAS: 1357920-84-3)

Belizatinib is inhibitor of both anaplastic lymphoma kinase (ALK) and tropomyosin-related kinases (TRK). Belizatinib can bind to and inhibit both ALK and TRK ki...

LOXO-101 sulfate
(CAS: 1223405-08-0)

The sulfate salt form of LOXO-101, also called Larotrectinib, is a ATP-competitive inhibitor of tropomyosin receptor kinases and is still under Phase II clinica...

CAS 342777-54-2 LM22B-10

LM22B-10
(CAS: 342777-54-2)

LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, which activates hippocampal and striatal TrkB and TrkC, and their downstream signaling, and increas...

CAS 1033769-28-6 GNF 5837

GNF 5837
(CAS: 1033769-28-6)

CAS 504433-23-2 GW 441756

GW 441756
(CAS: 504433-23-2)

GW 441756 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor (IC50 = 2 nM), reducing cell proliferation and potentiates the effects of chem...

Tavilermide
(CAS: 263251-78-1)

Tavilermide is a selective, small-molecule partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

Chemical Structure

CAS 1033769-28-6 GNF 5837

Quick Inquiry

Verification code

Featured Items