GNE-8525 - CAS 1196546-33-4
Catalog number: 1196546-33-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C31H30FN7O
Molecular Weight:
535.63
COA:
Inquire
Targets:
Trk Receptor
Description:
This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor efficacy in tumor xenograft model derived from the KM12 cell line. TRKA are believed to be the key oncogenic driver in many tumors including glioblastoma, melanoma and so on.
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Purity:
98%
Appearance:
Powder
Synonyms:
(R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
antitumor
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
OC1CCN(C2=NC=CC(C3=NC(C4=CN=C5C=CC(N6[C@@H](C7=CC=CC(F)=C7)CCC6)=NN54)=CC=C3)=C2)CC1
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