Glyburide (Glibenclamide) - CAS 10238-21-8
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Potassium Channel
Glyburide (Glibenclamide) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents.
Publictions citing BOC Sciences Products
  • >> More
1. Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes
Said Y. Khatib and Mark R. Boyett. Molecular and Cellular Biochemistry 242: 81–87, 2003.
The anti-diabetic sulfonylurea drugs, like glyburide, have been established as potent blockers of ATP dependent potassium channel (K+ATP) in the heart. They have been reported to cause positive inotropic effect in animals and human. Linden and Brooker reported a significant and large increase in contractility after an initial decrease in rabbit atrial muscle. Tolbutamide, first generation of sulfonylurea agent, was shown to have positive inotropic effect and to dramatically improve the recoverability of myocardial function of ischemic myocardium, which was suggested to be a cause of increased cardiac mortality. Glyburide, a second generation of sulfonylurea agent, was shown to have a positive inotropic effect in healthy volunteers. It produced a significant increase in myocardial contractility as indicated by increased ejection fraction and increased cardiac work. We reported a significant positive inotropic action for glyburide as shown by increased left ventricular pressure produced by 10 µM, in Langendorff isolated rabbit heart under normoxic conditions of perfusion. Glibenclamide elicited sustained positive inotropic effect in isolated guinea pig heart, improved functional recovery of ischemic myocardium at 45 min reperfusion and accelerated the onset of contracture thus speeding up cardiac arrest in rat and guinea-pig heart. Recently, glibenclamide was shown to increase intracellular calcium concentration in a dose dependent manner in cardiomyocytes. Smallwood et al. reported that glibenclamide attenuated action potential shortening (APD) during ischemia in a dose-related manner, but it did not effect on APD of the rabbit left ventricle. However, glyburide increased action potential duration at 95% repolarization in normoxic canine purkinje fibers.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Potassium Channel Products

Endoxifen HCl
(CAS: 1032008-74-4)

Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2. Endoxifen shows anti-estrogenic effects, and...

CAS 113559-13-0 E-4031

(CAS: 113559-13-0)

E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels.

(CAS: 668463-35-2)

RPR-260243 is a selective activator of the Human Ether-ago-go-Related Gene (hERG) (IC50 = 58 nM).

CAS 489402-47-3 ML213

(CAS: 489402-47-3)

ML213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) with > 80-fold selectivity against other related K+ channels, and enhances Kv7.2 and Kv7.4 cha...

CAS 65141-46-0 Nicorandil

(CAS: 65141-46-0)

Nicorandil is potassium channel activator.

CAS 289905-88-0 TRAM-34

(CAS: 289905-88-0)

TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM).

CAS 50679-08-8 Terfenadine

(CAS: 50679-08-8)

Terfenadine is a potent open-channel blocker of hERG (IC50=204 nM), formerly used for the treatment of allergic conditions.

CAS 94535-50-9 Levcromakalim

(CAS: 94535-50-9)

LevCromakalim is an ATP-sensitive K+channel(KATP) activator used in the management of hypertension in diabetes mellitus.

(CAS: 353262-04-1)

NS6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). NS6180 prevents T...

CAS 202821-81-6 BMS 191011

BMS 191011
(CAS: 202821-81-6)

BMS 191011 is a potent opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel. It is neuroprotectant in two distinct animal models of stroke...

CAS 18711-16-5 NS309

(CAS: 18711-16-5)

NS309 is a small- and intermediate- conductance Ca2+-activated K+ channels of SK and IK types whereas exhibits no activity at BK channels.

(CAS: 778564-77-5)

GYKI-16638 is Potassium channel and Sodium channel antagonist originated by Nonindustrial source. It is a novel antiarrhythmic agent.

ZM 260384
(CAS: 161229-62-5)

ZM 260384, a benzoxazine derivative, has been found to be a potassium channel agonist that was once studied against hypertension and thrombus.

CAS 19774-82-4 Amiodarone HCl

Amiodarone HCl
(CAS: 19774-82-4)

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

CAS 1260141-27-2 TAK438

(CAS: 1260141-27-2)

TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretio...

CAS 64190-70-1 Phe-Met-Arg-Phe, amide

Phe-Met-Arg-Phe, amide
(CAS: 64190-70-1)

Phe-Met-Arg-Phe, amide, also called as FMRF-NH2, belongs to Molluscan Cardioexcitatory Neuropeptide and dose dependently (ED50=23 nM) activates a K+current in t...

CAS 309-29-5 Doxapram

(CAS: 309-29-5)

Doxapram is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chem...

CAS 29094-61-9 Glipizide

(CAS: 29094-61-9)

Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. Glipizide is used to treat high blood sugar levels caused by a type...

CAS 149908-53-2 Azimilide

(CAS: 149908-53-2)

Azimilide, also called as Stedicor, a chlorophentlturany compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels. Phase III

Way 123398
(CAS: 138490-53-6)

Way 123398 is a class III antiarrhythmic agent. It is a Potassium channel antagonist originated by Wyeth. No preclinical development for Arrhythmias in USA was ...

Chemical Structure

CAS 10238-21-8 Glyburide (Glibenclamide)

Quick Inquiry

Verification code

Featured Items