Gly-Pro-Glu - CAS 32302-76-4
Catalog number:
32302-76-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C12H19N3O6
Molecular Weight:
301.30
COA:
Inquire
Targets:
Others
Description:
Gly-Pro-Glu is a neuroprotective agent and the N-terminal tripeptide of IGF-1.
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥98%
Appearance:
White powder
Synonyms:
GPE, Glycyl-prolyl-glutamic acid
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A neuroprotective agent and the N-terminal tripeptide of IGF-1.
Quality Standard:
Enterprise standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Milligrams-Grams
InChIKey:
JJGBXTYGTKWGAT-YUMQZZPRSA-N
InChI:
1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
Canonical SMILES:
C1CC(N(C1)C(=O)CN)C(=O)NC(CCC(=O)O)C(=O)O
1.The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist.
Vaaga CE1, Tovar KR2, Westbrook GL2. J Neurophysiol. 2014 Sep 15;112(6):1241-5. doi: 10.1152/jn.00290.2014. Epub 2014 Jun 18.
Glutamate acts as the universal agonist at ionotropic glutamate receptors in part because of its high degree of conformational flexibility. Other amino acids and small peptides, however, can activate N-methyl-d-aspartate (NMDA) receptors, albeit usually with lower affinity and efficacy. Here, we examined the action of glycine-proline-glutamate (GPE), a naturally occurring tripeptide formed in the brain following cleavage of IGF-I. GPE is thought to have biological activity in the brain, but its mechanism of action remains unclear. With its flanking glutamate and glycine residues, GPE could bind to either the agonist or coagonist sites on NMDA receptors, however, this has not been directly tested. Using whole cell patch-clamp recordings in combination with rapid solution exchange, we examined both steady-state currents induced by GPE as well as the effects of GPE on synaptically evoked currents. High concentrations of GPE evoked inward currents, which were blocked either by NMDA receptor competitive antagonists or the voltage-dependent channel blocker Mg(2+).
2.Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L-dopa in a Parkinson's animal model.
Minelli A1, Conte C, Cacciatore I, Cornacchia C, Pinnen F. Amino Acids. 2012 Sep;43(3):1359-67. doi: 10.1007/s00726-011-1210-x. Epub 2012 Jan 5.
Oxidative stress is a critical contributing factor to neurodegenerative disorders. Therefore, the inhibition of ROS formation, responsible for chronic detrimental neuroinflammation, is an important strategy for preventing the neurodegenerative disease and for neuroprotective therapy. Gly-Pro-Glu (GPE) is the N-terminal tripeptide of insulin-like growth factor-I, which is naturally cleaved in the plasma and brain tissues. GPE has neuroprotective effects since it crosses the blood-CSF and the functional CSF-brain barriers and binds to glial cells. It has been shown that GPE improves motor behaviour in rats after 6-OHDA lesion, although it does not rescue dopaminergic neurons. Thus, we hypothesized that the GPE therapeutic efficacy in a Parkinson model might be improved by combining GPE to L: -dopa. Here, we used an animal model that represents a progressive chronic Parkinson's disease (PD) model, characterized by high levels of oxidative stress and inflammation.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 590-46-5 Betaine hydrochloride

Betaine hydrochloride
(CAS: 590-46-5)

Betaine,which is isolated from the roots of Beta vulgaris, improves the amplification of DNA by reducing the formation of secondary structure in GC-rich regions...

CAS 101917-30-0 Sodium 4-pentynoate

Sodium 4-pentynoate
(CAS: 101917-30-0)

Sodium 4-pentynoate, an alkynylacetate analogue, can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acet...

Hemoglobin Modulators-1
(CAS: 1446321-46-5)

Hemoglobin Modulators-1, a substituted benzaldehyde compound that can modulate sickle hemoglobin (HbS) for treatment of disorders.

Epothilone F
(CAS: 208518-52-9)

Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin.

CAS 312756-74-4 RS-1

RS-1
(CAS: 312756-74-4)

RS-1, a cell-permeable sulfonamido-benzamide compound that increases the DNA binding activity of RAD51 (Kd range = 48-107 nM, value depends on cofactors present...

PD 130908
(CAS: 131505-02-7)

PD 130908 is an effective hypoxic cytotoxin as an analogue of RSU 1069, but less potent than the hypoxic cell radiosensitizer RSU 1069. Toxicity toward hypoxic ...

CAS 41060-15-5 Neobavaisoflavone

Neobavaisoflavone
(CAS: 41060-15-5)

Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40,...

Gly-Arg-Gly-Asp-Ser

Gly-Arg-Gly-Asp-Ser, a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin, has intermediate affinity to V3 and IIb3, which are the i...

CAS 445041-75-8 Intiquinatine

Intiquinatine
(CAS: 445041-75-8)

Intiquinatine may have potential anticancer activity.

CAS 14882-18-9 Bismuth Subsalicylate

Bismuth Subsalicylate
(CAS: 14882-18-9)

Bismuth Subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

CAS 58-27-5 Menadione

Menadione
(CAS: 58-27-5)

Menadione shows vitamin K activity, used as a nutritional supplement.

CAS 250159-48-9 Miriplatin hydrate

Miriplatin hydrate
(CAS: 250159-48-9)

Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin is a lipophilic pla...

CAS 84676-89-1 Astragaloside II

Astragaloside II
(CAS: 84676-89-1)

Astragaloside II is a saponin found in the root of Astragalus membranaceus (Fisch.) Bunge, which is known as huáng qí in Traditional Chinese Medicine. It has ca...

Cgp 38560
(CAS: 122088-76-0)

Cgp 38560 is a potent renin inhibitor and it can induce a dose-dependent decrease in angiotensin II and plasma renin activity and a long-lasting and dose-depend...

CAS 135062-02-1 Repaglinide

Repaglinide
(CAS: 135062-02-1)

Repaglinide is a potassium channel blocker, which lowers blood glucose by stimulating the release of insulin from the pancreas, used the treatment of type II di...

CAS 132-60-5 Cinchophen

Cinchophen
(CAS: 132-60-5)

Cinchophen is an analgesic drug that is frequently used to treat gout.

CAS 3440-28-6 Betamipron

Betamipron
(CAS: 3440-28-6)

Betamipron (INN) or N-benzoyl-β-alanine is a chemical compound which is used together with panipenem to inhibit panipenem uptake into the renal tubule and preve...

MK 410
(CAS: 40738-05-4)

MK 410 is an anti-inflammatory drug which can induce alterations in the immune system by the suppression of plasma neutral proteinase activity.

LY 164929
(CAS: 113573-18-5)

This active molecular is a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.

CAS 16051-77-7 Isosorbide mononitrate

Isosorbide mononitrate
(CAS: 16051-77-7)

A coronary vasodilator that does not require hepatic biotransformation

Chemical Structure

CAS 32302-76-4 Gly-Pro-Glu

Quick Inquiry

Verification code

Featured Items