|Description||O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor. It could reduce the inhibitor's ability to inhibit MGMT.|
Zebularine is a nucleoside analog of cytidine. It is a "transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrat...
Lomeguatrib, also known as PaTrin-2, is a potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase. Lomeguatrib is also a nontoxic low-molecular weight pseudos...
SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatme...
DC-05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 10.3 uM. It has significant selectivity toward other AdoMe...
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes.
DC_517 is a novel selective non-nucleoside inhibitor of DNMT1. (IC50 = 1.7 μM), was found to be more potent than DC_05.
Glucose-conjugated MGMT inhibitor
O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor. It could reduce the inhibitor's ability to inhibit MGMT.
Decitabine is a potent inhibitor of DNA methylation, used to treat myelodysplastic syndrome (MDS).