GLPG-0187 - CAS 1320346-97-1
Catalog number:
1320346-97-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H37N7O5S
Molecular Weight:
595.719
COA:
Inquire
Targets:
Integrin
Description:
GLPG-0187 is a small molecule integrin receptor antagonist (IRA) with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3, αvβ5, αvβ6 and α5β1 (IC50s = 1.2-3.7 nM). Integrin receptors are expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration. This compound shows an inhibitory activity of angiogenesis, bone-resorption and tumor, which is hopefully used as an anticancer drug.
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Brife Description:
integrin receptor antagonist (IRA), integrin receptor αv, cancer
Purity:
≥98 %
Appearance:
Solid Powder
Synonyms:
GLPG0187; UNII-43A5P87Z4T; 43A5P87Z4T; SCHEMBL2372722; CHEMBL3319236; (2S)-3-[[2,5-dimethyl-6-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl]pyrimidin-4-yl]amino]-2-[(4-methoxyphenyl)sulfonylamino]propanoic acid
Solubility:
Soluble in DMSO.
Storage:
Store in a cool and dry place and at 0-4 ℃ for short term (days to weeks) or -66 ℃ for long term (months to years).
MSDS:
Inquire
Application:
An integrin receptor antagonist (IRA) can be used as an anticancer drug.
Shelf Life:
2 years
InChIKey:
CXHCNOMGODVIKB-VWLOTQADSA-N
InChI:
InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23)32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1
Canonical SMILES:
CC1=C(N=C(N=C1NCC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)OC)C)N3CCC(CC3)C4=NC5=C(CCCN5)C=C4
Current Developer:
Galapagos NV
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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