Ginsenosides - CAS 74749-74-9
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Ginsenosides, also known as panaxosides, are found in the plant genus Panax (ginseng). It was widely used in the traditional Chinese medicine, and currently it is used as a dietary supplement.
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1.[Study on UPLC fingerprint of red ginseng based on good separation and good purity of chromatographic peaks].
Feng WH;Li C;Ji LN;Yang LX;Rong LX;Chen LM;Yi H;Wang ZM Zhongguo Zhong Yao Za Zhi. 2016 Oct;41(20):3798-3804. doi: 10.4268/cjcmm20162015.
This study is to establish the UPLC fingerprint of red ginseng. The separation was performed on a Waters Acquity BEH C₁₈ column (2.1 mm × 50 mm,1.7 μm), with the mobile phase consisting of acetonitrile and water for gradient elution. The detection wavelength was set at 203 nm. The UPLC fingerprint of red ginseng was established by using sample chromatography of 22 different purchase areas and 26 common peaks were found. Compared with the reference substances, 11 of the common peaks were identified as ginsenosides Rg₁, ginsenoside Re, ginsenoside Rf, ginsenoside Rh₁, ginsenoside Rg₂, ginsenoside Rb₁, 20(S)-ginsenoside F₁, ginsenoside Rb₂, ginsenoside Rb3, 20(S)-ginsenoside Rg₃ and 20(R)-ginsenoside Rg₃, respectively. It is worth noting that 20(S)-ginsenoside Rg₃ and 20(R)-ginsenoside Rg₃ are the characteristic ingredients of red ginseng, and they could be used not only for distinguishing red ginseng and ginseng, but also for process controlling of the preparation of red ginseng. The similarity was analyzed with' Similarity Evaluation System for Chromatographic Fingerprint of Chinese Materia Medica, and the similarity of 18 batches samples is up to 0.9. Compared to the literature methods, the method is simple, time-saving,specific for the separation of ginsenosides from red ginseng.
2.Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4.
Su F;Xue Y;Wang Y;Zhang L;Chen W;Hu S Antimicrob Agents Chemother. 2015 Sep;59(9):5654-63. doi: 10.1128/AAC.01381-15. Epub 2015 Jul 6.
We previously demonstrated that ginsenosides Rg1 and Re enhanced the immune response in C3H/HeB mice but not in C3H/HeJ mice carrying a mutation in the Tlr4 gene. The results of the present study showed that both Rg1 and Re inhibited mRNA expression and production of proinflammatory mediators that included tumor necrosis factor α, interleukin-1β, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase from lipopolysaccharide (LPS)-stimulated macrophages. Rg1 was found to be distributed both extracellularly and intracellularly but Re was located only extracellularly to compete with LPS for binding to Toll-like receptor 4. Preinjection of Rg1 and Re into rats suppressed LPS-induced increases in body temperature, white blood cell counts, and levels of serum proinflammatory mediators. Preinjection of Rg1 and Re into mice prevented the LPS-induced decreases in total white blood cell counts and neutrophil counts, inhibited excessive expression of multiple proinflammatory mediators, and successfully rescued 100% of the mice from sepsis-associated death. More significantly, when administered after lethal LPS inoculation, Rg1, but not Re, still showed a potent antisepsis effect and protected 90% of the mice from death.
3.Antiviral activity of 20(
Kang S;Im K;Kim G;Min H J Ginseng Res. 2017 Oct;41(4):496-502. doi: 10.1016/j.jgr.2016.08.010. Epub 2016 Sep 1.
BACKGROUND: ;Ginsenosides are the major components of ;Panax ginseng; Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus.;METHODS: ;The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene.;RESULTS: ;20(;R;)-Ginsenoside Rh2 inhibited the replication and proliferation of murine gammaherpesvirus 68 (MHV-68), and its half-maximal inhibitory concentration (IC;50;) against MHV-68 was estimated to be 2.77 μM. In addition, 20(;R;)-ginsenoside Rh2 inhibited 12-;O;-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpesvirus in the Kaposi's sarcoma-associated herpesvirus (KSHV)-positive cell line BC3.;CONCLUSION: ;Our results indicate that 20(;R;)-ginsenoside Rh2 can inhibit the replication of mouse and human gammaherpesviruses, and thus, has the potential to treat gammaherpesvirus infection.
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CAS 74749-74-9 Ginsenosides

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