Ginsenoside Rh2 - CAS 78214-33-2
Catalog number:
78214-33-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C36H62O8
Molecular Weight:
622.88
COA:
Inquire
Targets:
Others
Description:
Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng. It is a potent anti-inflammatory and anticancer drug and exhibits antibacterial effects in vitro. It also has antitumor, antidiabetic, antiallergic effects. It inhibited the growth of cultured human UL cells in vitro. It reduced the activity of oestrogen receptor alpha (ERα) and c-Src, increased p38 MAPK activity in UL cells by using ELISA, real-time RT-PCR and Western blot methods. It increased the levels of miR-497, which bound to 3′UTR of VEGF-A mRNA to inhibit its translation. It suppressed growth of uterine leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent manner. It can suppress RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions. It potently reverses memory impairment caused by scopolamine, it might improve learning deficits, also have the memory-enhancing effects of RGB. It can suppress growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity. It can inhibit the tendency of apoptosis and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
White to Off-White Solid
Synonyms:
(2R,3R,4S,5R,6R)-2-[[(10S,12S,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6 -methyl-hept-5-en-2-yl]-4,4,10,14,17-pentamethyl-2,3,5,6,7,8,9,11,12,1 3,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxyme thyl)oxane-3,4,5-triol;(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside;b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl;20(S)-Ginsenoside Rh2;20(S)-Rh2
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
It is a potent anti-inflammatory and anticancer drug and exhibits antibacterial effects in vitro. It also has antitumor, antidiabetic, antiallergic effects. It potently reverses memory impairment caused by scopolamine, it might improve learning deficits, also have the memory-enhancing effects of RGB. It can inhibit the tendency of apoptosis and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
726.4±60.0 °C | Condition: Press: 760 Torr
Melting Point:
139-144 °C
Density:
1.19±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
CKUVNOCSBYYHIS-IRFFNABBSA-N
InChI:
InChI=1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s
Canonical SMILES:
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)O)C
1.The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation.
Chen F1,2, Zhang B3, Sun Y4,5, Xiong ZX6,7, Peng H8,9, Deng ZY10,11, Hu JN12,13. Nutrients. 2016 Apr 25;8(5). pii: E244. doi: 10.3390/nu8050244.
Ginsenoside Rh2 is a potential pharmacologically active metabolite of ginseng. Previously, we have reported that an octyl ester derivative of ginsenoside Rh2 (Rh2-O), has been confirmed to possess higher bioavailability and anticancer effect than Rh2 in vitro. In order to better assess the possibility that Rh2-O could be used as an anticancer compound, the underlying mechanism was investigated in this study. The present results revealed that lysosomal destabilization was involved in the early stage of cell apoptosis in HepG2 cells induced by Rh2-O. Rh2-O could induce an early lysosomal membrane permeabilization with the release of lysosomal protease cathepsins to the cytosol in HepG2 cells. The Cat B inhibitor (leu) and Cat D inhibitor (pepA) inhibited Rh2-O-induced HepG2 apoptosis as well as tBid production and Δφm depolarization, indicating that lysosomal permeabilization occurred upstream of mitochondrial dysfunction. In addition, Rh2-O induced a significant increase in the protein levels of DRAM1 and Bax (p < 0.
2.Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy.
Yang Z1, Zhao T2, Liu H2, Zhang L1. Sci Rep. 2016 Jan 19;6:19383. doi: 10.1038/srep19383.
Hepatocellular carcinoma (HCC) is the most common liver cancer, with a very poor prognosis. There is an urgent need for an effective therapy for HCC. Ginsenoside Rh2 (GRh2) has been shown to significantly inhibit growth of some types of cancer, whereas its effects on HCC have not been examined. Here, we treated human HCC cells with different doses of GRh2, and found that GRh2 dose-dependently reduced HCC viability, in either CCK-8 assay or MTT assay. The effects of GRh2 on the cancer stem cells (CSCs)-like cells were determined by aldefluor flow cytometry and by tumor sphere formation, showing that GRh2 dose-dependently decreased the number of these CSCs-like cells in HCC. Autophagy-associated protein and β-catenin level were measured in GRh2-treated HCC cells by Western blot, showing that GRh2 increased autophagy and inhibited β-catenin signaling. Expression of short hairpin small interfering RNA (shRNA) for Atg7 in HCC cells completely abolished the effects of GRh2 on β-catenin and cell viability, while overexpression of β-catenin abolished the effects of GRh2 on autophagy and cell viability.
3.Esterification of Ginsenoside Rh2 Enhanced Its Cellular Uptake and Antitumor Activity in Human HepG2 Cells.
Chen F1, Deng ZY1,2, Zhang B1, Xiong ZX2, Zheng SL2, Tan CL2, Hu JN1,2. J Agric Food Chem. 2016 Jan 13;64(1):253-61. doi: 10.1021/acs.jafc.5b05450. Epub 2015 Dec 28.
Our previous research had indicated that the octyl ester derivative of ginsenoside Rh2 (Rh2-O) might have a higher bioavailability than Rh2 in the Caco-2 cell line. The aim of this study was to investigate the cellular uptake and antitumor effects of Rh2-O in human HepG2 cells as well as its underlying mechanism compared with Rh2. Results showed that Rh2-O exhibited a higher cellular uptake (63.24%) than Rh2 (36.76%) when incubated with HepG2 cells for 24 h. Rh2-O possessed a dose- and time-dependent inhibitory effect against the proliferation of HepG2 cells. The IC50 value of Rh2-O for inhibition of HepG2 cell proliferation was 20.15 μM, which was roughly half the value of Rh2. Rh2-O induced apoptosis of HepG2 cells through a mitochondrial-mediated intrinsic pathway. In addition, the accumulation of ROS was detected in Rh2-O-treated HepG2 cells, which participated in the apoptosis of HepG2 cells. Conclusively, the findings above all suggested that Rh2-O as well as Rh2 inducing HepG2 cells apoptosis might involve similar mechanisms; however, Rh2-O had better antitumor activities than Rh2, probably due to its higher cellular uptake.
4.Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-β1/Smad Pathway.
Vinoth Kumar R1, Oh TW2, Park YK3,4. Neurochem Res. 2016 May;41(5):951-7. doi: 10.1007/s11064-015-1804-x. Epub 2016 Jan 6.
Microglia activation plays an important role in neuroinflammation and contributes to several neurological disorders. Hence, inhibition of both microglia activation and pro-inflammatory cytokines may lead to the effective treatment of neurodegenerative diseases. In this study, we found that GRh2 inhibited the inflammatory response to lipopolysaccharide (LPS) and prevented the LPS-induced neurotoxicity in microglia cells. GRh2 significantly decreased the generation of nitric oxide production, and tumor necrosis factor-α, interleukin (IL)-6, IL-1β, cyclooxygenase-2 and inducible nitric oxide synthase in LPS-induced activated microglia cells. Furthermore, GRh2 (20 and 50 μM) significantly increased TGF-β1 expression and reduced the expression of Smad. These results suggest that GRh2 effectively inhibits microglia activation and production of pro-inflammatory cytokines via modulating the TGF-β1/Smad pathway.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 1235481-90-9 P7C3-A20

P7C3-A20
(CAS: 1235481-90-9)

P7C3-A20, an analogue of P7C3, is a neuroprotective compound which inhibits mature neuronal cell death while also increasing the net magnitude of postnatal neur...

CAS 200189-97-5 CGP 3466B maleate

CGP 3466B maleate
(CAS: 200189-97-5)

CGP 3466B maleate, a potent anti-apoptotic drug, is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. CGP 3466B maleate was tested in...

20-O-Acetylingenol-3-angelate
(CAS: 82425-35-2)

20-O-Acetylingenol-3-angelate is a natural compound extracted from Euphorbia conspicua N. E. Br. It is used as molluscicidal agent, anti-cancer agent and cytost...

CAS 406-90-6 Flurossene

Flurossene
(CAS: 406-90-6)

Fluroxene is a volatile, inhalational anesthetic, and was the first halogenated hydrocarbon anesthetic to be introduced.

CAS 6233-83-6 Oxytocin acetate

Oxytocin acetate
(CAS: 6233-83-6)

Oxytocin acetate is a mammalian neurohypophysial hormone. Its actions are mediated by specific, high-affinity oxytocin receptors. Oxytocin is normally produced ...

CAS 13422-55-4 Methylcobalamin

Methylcobalamin
(CAS: 13422-55-4)

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthes...

ACT-246475
(CAS: 1159500-34-1)

This active molecular is a reversible and selective platelet P2Y12 receptor antagonist. IC50 value of ACT-246475 is 8.0 nM. ACT-246475 dose-dependently blocked ...

CAS 138-41-0 Carzenide

Carzenide
(CAS: 138-41-0)

Carzenide, a Sulfanilamide derivative, could be used as an intermediate to synthesize sorts of pharmaceuticals like carbonic anhydrase inhibitors.

U-75875
(CAS: 112190-24-6)

U-75875 is a protease inhibitor. It is also a peptidomimetic inhibitor and could inhibit HIV-1 gag-pol protein. It completely blocked HIV replication in human p...

CAS 53-03-2 Prednisone

Prednisone
(CAS: 53-03-2)

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

CAS 79551-86-3 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraen
(CAS: 79551-86-3)

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid is a potent vasoconstrictor produced in vascular smooth muscle cells. Its EC50 value is < 10 nM. It is a cytoch...

CAS 73334-07-3 Iopromide

Iopromide
(CAS: 73334-07-3)

Iopromide is a contrast medium produced by Bayer Healthcare. It is a low osmolar, non-ionic contrast agent for intravascular use. It can be used in radiographic...

CAS 1345808-25-4 Arginase inhibitor 1

Arginase inhibitor 1
(CAS: 1345808-25-4)

Arginase inhibitor 1 is active in a recombinant cellular assay overexpressing humanarginase I (CHO cells). It is 28% orally bioavailable and significantly reduc...

CAS 79-83-4 D-Pantothenic acid

D-Pantothenic acid
(CAS: 79-83-4)

D-Pantothenic acid, also called vitamin B5, is a water-soluble vitamin and an essential nutrient for many animals.

CAS 1065559-56-9 SMND-309

SMND-309
(CAS: 1065559-56-9)

SMND-309 is a novel derivative of salvianolic acid B, and has shown protective effects against rat cortical neuron damage in vitro and in vivo.

CAS 7424-00-2 4-Chloro-DL-phenylalanine

4-Chloro-DL-phenylalanine
(CAS: 7424-00-2)

4-Chloro-DL-phenylalanine is a pharmaceutical intermediate. It acts as a selective and irreversible inhibitor of tryptophan hydroxylase. It is a rate-limiting e...

EAD-1
(CAS: 1644388-26-0)

EAD-1, a chloroquinoline derivative, has been found to be an autophagy inhibitor that exhibit antiproliferative effct in lung and pancreatic cancer cells so tha...

CAS 155521-46-3 Alisol G

Alisol G
(CAS: 155521-46-3)

Alisol G, a triterpenoid isolated from the rhizome of Alisma orientale, has hCE2 inhibitory effects.

Ritobegron ethyl hydrochloride
(CAS: 476333-91-2)

Ritobegron is a potential Bladder selectivity of the novel β₃-agonist.

CAS 1462249-75-7 PFK-158

PFK-158
(CAS: 1462249-75-7)

PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of...

Chemical Structure

CAS 78214-33-2 Ginsenoside Rh2

Quick Inquiry

Verification code

Featured Items