|Description||Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng. It is a potent anti-inflammatory and anticancer drug and exhibits antibacterial effects in vitro. It also has antitumor, antidiabetic, antiallergic effects. It inhibited the growth of cultured human UL cells in vitro. It reduced the activity of oestrogen receptor alpha (ERα) and c-Src, increased p38 MAPK activity in UL cells by using ELISA, real-time RT-PCR and Western blot methods. It increased the levels of miR-497, which bound to 3′UTR of VEGF-A mRNA to inhibit its translation. It suppressed growth of uterine leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent manner. It can suppress RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions. It potently reverses memory impairment caused by scopolamine, it might improve learning deficits, also have the memory-enhancing effects of RGB. It can suppress growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity. It can inhibit the tendency of apoptosis and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins.|
|Appearance||White to Off-White Solid|
|Synonyms||(2R,3R,4S,5R,6R)-2-[[(10S,12S,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6 -methyl-hept-5-en-2-yl]-4,4,10,14,17-pentamethyl-2,3,5,6,7,8,9,11,12,1 3,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxyme thyl)oxane-3,4,5-triol;(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl beta-D-glucopyranoside;b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl;20(S)-Ginsenoside Rh2;20(S)-Rh2|
|Solubility||10 mM in DMSO|
|Application||It is a potent anti-inflammatory and anticancer drug and exhibits antibacterial effects in vitro. It also has antitumor, antidiabetic, antiallergic effects. It potently reverses memory impairment caused by scopolamine, it might improve learning deficits, also have the memory-enhancing effects of RGB. It can inhibit the tendency of apoptosis and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Boiling Point||726.4±60.0 °C | Condition: Press: 760 Torr|
|Melting Point||139-144 °C|
|Density||1.19±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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