Ginsenoside Rg1 - CAS 22427-39-0
Catalog number: 22427-39-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C42H72O14
Molecular Weight:
801.01
COA:
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Targets:
Glucocorticoid Receptor
Description:
Ginsenoside Rg1 is extrected from the roots of Panax ginseng C. A. Mey. It has estrogen-like activity and should be classified as a novel class of potent phytoestrogen. It protects against arthitis through osteoclast differentiation inhibition. It inhibit
Purity:
>98%
Appearance:
White powder
Synonyms:
Panaxoside A;Dammarane, β-D-glucopyranoside deriv.;Ginsenoside A2;Panaxoside Rg1;Panaxsaponin Rg1;Sanchinoside C1;Sanchinoside Rg1;(3β,6α,12β)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-β-D-glucopyranoside
Solubility:
Soluble to ≥ 7.6 mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -87℃ for long term (months to years).
MSDS:
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Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
898.5±65.0 °C | Condition: Press: 760 Torr
Melting Point:
191-194 °C
Density:
1.33±0.1 g/cm3
InChIKey:
YURJSTAIMNSZAE-HHNZYBFYSA-N
InChI:
1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3/t21-,22+,23-,24+,25+,26+,27-,28
Canonical SMILES:
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)O)C)O)C)OC6C(C(C(C(O6)CO)O)O)O)C
1.Ginsenoside Rg1 exerts a protective effect against Aβ25-35-induced toxicity in primary cultured rat cortical neurons through the NF-κB/NO pathway.
Wu J1, Yang H1, Zhao Q1, Zhang X1, Lou Y2. Int J Mol Med. 2016 Mar;37(3):781-8. doi: 10.3892/ijmm.2016.2485. Epub 2016 Feb 8.
Ginsenoside Rg1 (Rg1) is a multipotent triterpene saponin extracted from ginseng, and has been proven to act as a nootropic agent against various types of neurological damage. The present study was designed to investigate the neuroprotective effect and the underlying mechanisms of Rg1 on apoptosis induced by β-amyloid peptide 25-35 (Aβ25-35) in primary cultured cortical neurons. The primary neurons were preincubated with 20 µM Rg1 for 24 h and exposed to 10 µM Aβ25-35 for 72 h. In the present study, we found that Rg1 prevented nuclear factor κ-light-chain‑enhancer of activated B cells (NF-κB) nuclear translocation and IκB-α phosphorylation in primary cultured cortical neurons after Aβ25-35 exposure by scavenging excess reactive oxygen species (ROS); ROS was measured using DCFDA and examined using a fluorescence microscope. In addition, Rg1 successfully suppressed Aβ25‑35-inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in a NF-κB-dependent manner; the suppression of NO was clearly illustrated by the NO production assay.
2.Ginsenoside Rg1 reverses stress-induced depression-like behaviors and BDNF expression within the prefrontal cortex.
Zhu X1, Gao R1,2, Liu Z1, Cheng Z1, Qi Y1, Fan C1, Yu SY1,3. Eur J Neurosci. 2016 Apr 8. doi: 10.1111/ejn.13255. [Epub ahead of print]
Depression is a major neuropsychiatric disorder which exerts deleterious effects upon public health. However, the neuronal mechanisms of depression remain largely uncharacterized, which has retarded the identification and development of effective therapeutic tools for the treatment of this disorder. The aim of this study was to explore the neuronal mechanisms underlying the protective effects of ginsenoside Rg1, a natural steroidal saponin found in ginseng, against chronic stress induced depression.The results showed that chronic administration of ginsenoside Rg1 (40 mg/kg, i.p., 5 weeks) significantly ameliorated depression-like behaviors in rats as assessed in the sucrose preference and forced swim tests. Furthermore, chronic stress decreased the phosphorylation levels of the extracellular signal-regulated kinase (ERK) and the CAMP-response element binding protein (CREB) in the prefrontal cortex (PFC) as well as producing a reduction of brain-derived neurotrophic factor (BDNF) expression.
3.Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model.
Li F1, Wu X2, Li J3, Niu Q2. Mol Med Rep. 2016 Apr 12. doi: 10.3892/mmr.2016.5103. [Epub ahead of print]
The complex etiopathogenesis of Alzheimer's disease (AD) has limited progression in the identification of effective therapeutic agents. Amyloid precursor protein (APP) and presenilin‑1 (PS1) are always overexpressed in AD, and are considered to be the initiators of the formation of β‑amyloid plaques and the symptoms of AD. In the present study, a transgenic AD model, constructed via the overexpression of APP and PS1, was used to verify the protective effects of ginsenoside Rg1 on memory performance and synaptic plasticity. AD mice (6‑month‑old) were treated via intraperitoneal injection of 0.1‑10 mg/kg ginsenoside Rg1. Long‑term memory, synaptic plasticity, and the levels of AD‑associated and synaptic plasticity‑associated proteins were measured following treatment. Memory was measured using a fear conditioning task and protein expression levels were investigated using western blotting. All the data was analyzed by one-way analysis of variance or t‑test.
4.Vaccine adjuvant ginsenoside Rg1 enhances immune responses against hepatitis B surface antigen in mice.
Yuan D1,2, Yuan Q1, Cui Q1, Liu C1, Zhou Z1, Zhao H1, Dun Y1, Wang T1, Zhang C1. Can J Physiol Pharmacol. 2016 Mar 4:1-6. [Epub ahead of print]
The adjuvant effect of ginsenoside Rg1 on immune responses against hepatitis B surface antigen (HBsAg) in mice was investigated. Female BALB/c mice were subcutaneously injected with saline or HBsAg antigen with or without Rg1 on days 7 and 21. Samples were collected 2 weeks after the boosting for the detection of anti-HBsAg immunoglobulin G (IgG) isotypes in sera and gamma interferon (IFN-γ) and interleukin-4 (IL-4) produced in splenocytes. The innate and adaptive immune responses were measured in mice immunized as described above. The results showed that ginsenoside Rg1 had adjuvant properties in stimulating IgG, splenocyte proliferation, and mRNA expression of cytokines IFN-γ and IL-4, as well as the expression of cell surface marker TLR4 in the HBsAg-immunized mice. These results indicate that Rg1 enhances both Th1 (IgG2b and IFN-γ) and Th2 (IgG1 and IL-4) responses. In addition, the TLR4 signaling pathway is involved in the adjuvant activities of ginsenoside Rg1.
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CAS 22427-39-0 Ginsenoside Rg1

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