Ginsenoside Rd2 - CAS 83480-64-2
Catalog number: B0005-479871
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Molecular Formula:
C47H80O17
Molecular Weight:
917.13
COA:
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Chemical Family:
Triterpenoids
Description:
Ginsenoside Rd2 is a composition of roots of Panax ginseng. Ginsenoside Rd is a primary constituent of the ginseng rhizome and the administration of ginsenoside Rd significantly increased the reduced GSHPx and glutathione reductase activity.
Ordering Information
Catalog Number Size Price Stock Quantity
B0005-479871 10mg $799 In stock
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Purity:
> 98%
Appearance:
White solid powder
Synonyms:
β-​D-​Glucopyranoside, (3β,​12β)​-​3-​(β-​D-​glucopyranosyloxy)​-​12-​hydroxydammar-​24-​en-​20-​yl 6-​O-​α-​L-​arabinopyranosyl-; (3β,12β)-3-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside; 3-O-Glucosylginsenoside C Y; 3-O-β-D-Glucopyranosylginsenoside C-Y; Ginsenoside C-O
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -42℃ for long term (months to years).
MSDS:
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Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
Boiling Point:
982.5±65.0 °C | Condition: Press: 760 Torr
Density:
1.36±0.1 g/cm3
1.Comparative study on chemical components and anti-inflammatory effects of Panax notoginseng flower extracted by water and methanol.
Ma LJ;Liu F;Zhong ZF;Wan JB J Sep Sci. 2017 Dec;40(24):4730-4739. doi: 10.1002/jssc.201700641. Epub 2017 Nov 27.
Methanol and water are commonly used solvents for chemical analysis and traditional decoction, respectively. In the present study, a high-performance liquid chromatography with ultraviolet detection method was developed to quantify 11 saponins in Panax notoginseng flower extracted by aqueous solution and methanol, and chemical components and anti-inflammatory effects of these two extracts were compared. The separation of 11 saponins, including notoginsenoside Fc and ginsenoside Rc, was well achieved on a Zorbax SB C18 column. This developed method provides an adequate linearity (r;2;  > 0.999), repeatability (RSD < 4.26%), inter- and intraday variations (RSD < 3.20%) with recovery (94.7-104.1%) of 11 saponins concerned. Our data indicated that ginsenoside biotransformation in PNF was found, when water was used as the extraction solvent, but not methanol. Specifically, the major components of Panax notoginseng flower, ginsenosides Rb1, Rc, Rb2, Rb3, and Rd, can be near completely transformed to the minor components, gypenoside XVII, notoginsenoside Fe, ginsenoside Rd2, notoginsenoside Fd, and ginsenoside F2, respectively. Total protein isolated from Panax notoginseng flower is responsible for this ginsenoside biotransformation.
2.Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.
Zhang YW;Dou DQ;Zhang L;Chen YJ;Yao XS Planta Med. 2001 Jul;67(5):417-22.
Gap junctions have been shown or are believed to be involved in the pathogenesis of many inherited and acquired human diseases. Agents that regulate the gap junction-mediated intercellular communication (GJIC) function may facilitate prevention and treatment of GJIC-involved diseases. In the present study we examined the effects of 27 ginsenosides isolated from Panax ginseng on GJIC. The results show that compounds 1 (oleanolic acid), 2 (ginsenoside-R0), 3 (ginsenoside-Rb1), 5 (ginsenoside-Rb2), 7 (ginsenoside-Rd), 8 (ginsenoside-Rg3), 12 (panaxadial), 13 (notoginsenoside-R4), 17 [ginsenoside-Rg2 (20S)], 18 (ginsenoside-Rf), and 26 (ginsenoside-F3) did not obviously affect GJIC, whereas compounds 4 (ginsenoside-Rc), 6 (ginsenoside-Rb3), 9 (ginsenoside-Rd2), 10 (notoginsenoside-Fe), 11 (ginsenoside-Rh2),14 (ginsenoside-Ra1), 15 (ginsenoside-Re), 16 [ginsenoside-Rg2 (20R)], 19 (ginsenoside-Ia), 20 [ginsenoside-Rh1 (20S)], 21 [ginsenoside-Rh1 (20R)], 22 (ginsenoside-F1), 23 (protopanaxatriol), 24 (panaxatriol), 25 (ginsenoside-Rg1), and 27 (chikusetsaponin-L8) induced GJIC reductions at various degrees. Compounds 2, 7, and 8 protected against the tyrosine phosphatase inhibitor vanadate-induced GJIC reduction, while compounds 1, 5, 7, and 17 inhibited the cytokine interleukin 1 alpha (IL-1alpha)-induced reduction in GJIC.
3.Bioconversion of ginsenosides Rb(1), Rb(2), Rc and Rd by novel β-glucosidase hydrolyzing outer 3-O glycoside from Sphingomonas sp. 2F2: cloning, expression, and enzyme characterization.
Wang L;Liu QM;Sung BH;An DS;Lee HG;Kim SG;Kim SC;Lee ST;Im WT J Biotechnol. 2011 Nov 10;156(2):125-33. doi: 10.1016/j.jbiotec.2011.07.024. Epub 2011 Aug 27.
A new β-glucosidase gene (bglSp) was cloned from the ginsenoside converting Sphingomonas sp. strain 2F2 isolated from the ginseng cultivating filed. The bglSp consisted of 1344 bp (447 amino acid residues) with a predicted molecular mass of 49,399 Da. A BLAST search using the bglSp sequence revealed significant homology to that of glycoside hydrolase superfamily 1. This enzyme was overexpressed in Escherichia coli BL21 (DE3) using a pET21-MBP (TEV) vector system. Overexpressed recombinant enzymes which could convert the ginsenosides Rb(1), Rb(2), Rc and Rd to the more pharmacological active rare ginsenosides gypenoside XVII, ginsenoside C-O, ginsenoside C-Mc(1) and ginsenoside F(2), respectively, were purified by two steps with Amylose-affinity and DEAE-Cellulose chromatography and characterized. The kinetic parameters for β-glucosidase showed the apparent K(m) and V(max) values of 2.9±0.3 mM and 515.4±38.3 μmol min(-1)mg of protein(-1) against p-nitrophenyl-β-d-glucopyranoside. The enzyme could hydrolyze the outer C3 glucose moieties of ginsenosides Rb(1), Rb(2), Rc and Rd into the rare ginsenosides Gyp XVII, C-O, C-Mc(1) and F(2) quickly at optimal conditions of pH 5.0 and 37°C. A little ginsenoside F(2) production from ginsenosides Gyp XVII, C-O, and C-Mc(1) was observed for the lengthy enzyme reaction caused by the side ability of the enzyme.
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CAS 83480-64-2 Ginsenoside Rd2

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