Ginsenoside Rb2 - CAS 11021-13-9
Catalog number:
11021-13-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C53H90O22
Molecular Weight:
1079.27
COA:
Inquire
Targets:
Others
Description:
Ginsenoside Rb2, a sort of saponin substance, is extracted from ginseng and could inhibit the tumor growth and metastasis by destructing the angiogenesis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
White powder
Synonyms:
Beta-d-glucopyranoside,(3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta;-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-;20-[(6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-
Solubility:
10 mM in water
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Ginsenoside Rb2 is extracted from ginseng and could inhibit the tumor growth and metastasis by destructing the angiogenesis.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
NODILNFGTFIURN-GZPRDHCNSA-N
InChI:
InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)7
Canonical SMILES:
CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(CO8)O)O)O)O)O)O)C
1.Ginsenoside Rb2 Attenuates UV-B Radiation-Induced Reactive Oxygen Species and Matrix Metalloproteinase-2 through Upregulation of Antioxidant Components in Human Dermal Fibroblasts.
Oh SJ1, Kim K, Lim CJ. Pharmacology. 2015;96(1-2):32-40. doi: 10.1159/000431154. Epub 2015 May 30.
AIMS: The antiphotoaging activities of ginsenoside Rb2 on the skin, one of the predominant protopanaxadiol-type ginsenosides, were evaluated in cultured human dermal fibroblasts.
2.Melanin Biosynthesis Inhibition Effects of Ginsenoside Rb2 Isolated from Panax ginseng Berry.
Lee DY1, Jeong YT2, Jeong SC3, Lee MK4, Min JW5, Lee JW1, Kim GS1, Lee SE1, Ahn YS1, Kang HC5, Kim JH6. J Microbiol Biotechnol. 2015 Dec 28;25(12):2011-5. doi: 10.4014/jmb.1505.05069.
Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, (1)H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.
3.Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet.
Jin Y1, Tian T2, Ma Y2, Xu H2, Du Y3. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:112-9. doi: 10.1016/j.jchromb.2015.06.027. Epub 2015 Jul 17.
A sensitive, specific and rapid liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for analysis of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma using sulfamethoxazole as an internal standard (IS). Separation was conducted out on an Agilent Eclipse XDB C18 column with liner gradient elution using acetonitrile (A) and 0.1% aqueous acetic acid (B). A tandem mass spectrometric detection was conducted using multiple reaction monitoring (MRM) via an electrospray ionization (ESI) source. A novel multi-determination-periods program was executed to achieve a higher sensitivity by setting three scanning periods. All analytes exhibited good linearity within the concentration range (r>0.9973). The lower limits of quantitation (LLOQ) of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin were 2.64, 4.32, 2.32 and 1.56ng/mL, respectively. Intra-day and inter-day precisions of the investigated components exhibited an RSD within 8.
4.Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes.
Oh SJ1, Kim K, Lim CJ. Biosci Biotechnol Biochem. 2015;79(7):1075-81. doi: 10.1080/09168451.2015.1020752. Epub 2015 Mar 16.
Ginsenosides, also known as ginseng saponins, are the principal bioactive ingredients of ginseng, which are responsible for its diverse pharmacological activities. The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation. When the cultured keratinocytes were subjected to Rb2 prior to UV-B irradiation, Rb2 displayed suppressive activities on UV-B-induced reactive oxygen species elevation and matrix metalloproteinase-2 expression and secretion. However, Rb2 at the used concentrations was unable to modulate cellular survivals in the UV-B-irradiated keratinocytes. In brief, Rb2 possesses a protective role against the photoaging of human keratinocyte cells under UV-B irradiation.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 199666-03-0 Ro 61-8048

Ro 61-8048
(CAS: 199666-03-0)

Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Blood-brain ba...

CAS 5466-77-3 Octinoxate

Octinoxate
(CAS: 5466-77-3)

Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms used in sunscreens and other cosmetics

FR-181877
(CAS: 172936-99-1)

FR-181877, an oxopyridazin derivative, has been found to be a nonprostanoid PGI2 agonist and could restrain the aggregation of human platelets induced by ADP. I...

CAS 1184-16-3 NADP sodium salt

NADP sodium salt
(CAS: 1184-16-3)

Sodium Salt Hydrate form of NADP which is a coenzyme widely exist in living organism and commonly related to oxidation-reduction reactions.

ABT-515
(CAS: 189328-52-7)

BPH-652
(CAS: 157124-84-0)

BPH-652, also known as BMS-187745, has been found to be a SQS inhibitor that could probably be effective against S. aureus infections.

Gly-Phe-Arg

Gly-Phe-Arg, a superpotent synthetic tripeptide, mimics the mud-crab pumping pheromone.

CAS 66-84-2 D-Glucosamine Hydrochloride

D-Glucosamine Hydrochloride
(CAS: 66-84-2)

D-Glucosamine hydrochloride is present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants has been used as a standard to quan...

CAS 115-02-6 Azaserine

Azaserine
(CAS: 115-02-6)

Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine ana...

ONO3708
(CAS: 102191-05-9)

ONO3708 is a potent antagonist of the thromboxane A2/prostaglandin endoperoxide receptor in vitro and in vivo. It could play an important role in the pathogenes...

CAS 93265-81-7 Ropidoxuridine

Ropidoxuridine
(CAS: 93265-81-7)

Ropidoxuridine is a novel, orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR). It has radios...

CAS 28845-86-5 Docosatrienoic Acid

Docosatrienoic Acid
(CAS: 28845-86-5)

Docosatrienoic acid is a rare ω-3 fatty acid, not readily detected in normal phospholipid PUFA pools. Docosatrienoic acid inhibits LTB4 binding to pig neutrophi...

CAS 129558-76-5 Tolfenpyrad

Tolfenpyrad
(CAS: 129558-76-5)

Tolfenpyrad is used as foliar insecticide for the control of green peach aphids in broccoli.

CAS 1439399-58-2 CB-839

CB-839
(CAS: 1439399-58-2)

CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly...

CAS 301-00-8 Methyl linolenate

Methyl linolenate
(CAS: 301-00-8)

Methyl linolenate, a polyunsaturated fattly acid (PUFA), is an autoxidation product that is used to study the mechanisms and prevention of oxidation/peroxidatio...

Elamipretide
(CAS: 736992-21-5)

Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Vent...

CAS 121776-33-8 Furilazole

Furilazole
(CAS: 121776-33-8)

Furilazole, an oxazole derivative, is a herbicide commonly used for gramineous crops.

CAS 173352-39-1 Afobazole hydrochloride

Afobazole hydrochloride
(CAS: 173352-39-1)

Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any ...

CAS 959551-10-1 NIH-12848

NIH-12848
(CAS: 959551-10-1)

NIH-12848 is putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor (IC50= 1 μM) but did not inhibit the α and β PI5P4K isoforms at concentrat...

CAS 6899-04-3 DL-Glutamine

DL-Glutamine
(CAS: 6899-04-3)

DL-Glutamine is an unnatural amino acid and could be used for general biochemical research and drug synthesis.

Chemical Structure

CAS 11021-13-9 Ginsenoside Rb2

Quick Inquiry

Verification code

Featured Items