Ginsenoside Rb2 - CAS 11021-13-9
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Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Ginsenoside Rb2, a sort of saponin substance, is extracted from ginseng and could inhibit the tumor growth and metastasis by destructing the angiogenesis.
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Beta-d-glucopyranoside,(3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta;-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-;20-[(6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-
10 mM in water
-20ºC Freeze
Ginsenoside Rb2 is extracted from ginseng and could inhibit the tumor growth and metastasis by destructing the angiogenesis.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
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1.Ginsenoside Rb2 Attenuates UV-B Radiation-Induced Reactive Oxygen Species and Matrix Metalloproteinase-2 through Upregulation of Antioxidant Components in Human Dermal Fibroblasts.
Oh SJ1, Kim K, Lim CJ. Pharmacology. 2015;96(1-2):32-40. doi: 10.1159/000431154. Epub 2015 May 30.
AIMS: The antiphotoaging activities of ginsenoside Rb2 on the skin, one of the predominant protopanaxadiol-type ginsenosides, were evaluated in cultured human dermal fibroblasts.
2.Melanin Biosynthesis Inhibition Effects of Ginsenoside Rb2 Isolated from Panax ginseng Berry.
Lee DY1, Jeong YT2, Jeong SC3, Lee MK4, Min JW5, Lee JW1, Kim GS1, Lee SE1, Ahn YS1, Kang HC5, Kim JH6. J Microbiol Biotechnol. 2015 Dec 28;25(12):2011-5. doi: 10.4014/jmb.1505.05069.
Ginsenoside Rb2 (Gin-Rb2) was purified from the fruit extract of Panax ginseng. Its chemical structure was measured by spectroscopic analysis, including HR-FAB-MS, (1)H-NMR, and IR spectroscopy. Gin-Rb2 decreased potent melanogenesis in melan-a cells, with 23.4% at 80 μM without cytotoxicity. Gin-Rb2 also decreased tyrosinase and MITF protein expression in melan-a cells. Furthermore, Gin-Rb2 presented inhibition of the body pigmentation in the zebrafish in vivo system and reduced melanin contents and tyrosinase activity. These results show that Gin-Rb2 isolated from P. ginseng may be an effective skin-whitening agent via the in vitro and in vivo systems.
3.Simultaneous determination of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Weifuchun tablet.
Jin Y1, Tian T2, Ma Y2, Xu H2, Du Y3. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:112-9. doi: 10.1016/j.jchromb.2015.06.027. Epub 2015 Jul 17.
A sensitive, specific and rapid liquid chromatography-mass spectrometry (LC-MS) method was developed and validated for analysis of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin in rat plasma using sulfamethoxazole as an internal standard (IS). Separation was conducted out on an Agilent Eclipse XDB C18 column with liner gradient elution using acetonitrile (A) and 0.1% aqueous acetic acid (B). A tandem mass spectrometric detection was conducted using multiple reaction monitoring (MRM) via an electrospray ionization (ESI) source. A novel multi-determination-periods program was executed to achieve a higher sensitivity by setting three scanning periods. All analytes exhibited good linearity within the concentration range (r>0.9973). The lower limits of quantitation (LLOQ) of ginsenoside Rb1, naringin, ginsenoside Rb2 and oridonin were 2.64, 4.32, 2.32 and 1.56ng/mL, respectively. Intra-day and inter-day precisions of the investigated components exhibited an RSD within 8.
4.Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes.
Oh SJ1, Kim K, Lim CJ. Biosci Biotechnol Biochem. 2015;79(7):1075-81. doi: 10.1080/09168451.2015.1020752. Epub 2015 Mar 16.
Ginsenosides, also known as ginseng saponins, are the principal bioactive ingredients of ginseng, which are responsible for its diverse pharmacological activities. The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation. When the cultured keratinocytes were subjected to Rb2 prior to UV-B irradiation, Rb2 displayed suppressive activities on UV-B-induced reactive oxygen species elevation and matrix metalloproteinase-2 expression and secretion. However, Rb2 at the used concentrations was unable to modulate cellular survivals in the UV-B-irradiated keratinocytes. In brief, Rb2 possesses a protective role against the photoaging of human keratinocyte cells under UV-B irradiation.
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CAS 11021-13-9 Ginsenoside Rb2

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