Ginsenoside C-K - CAS 39262-14-1
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Not Intended for Therapeutic Use. For research use only.
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Ginsenoside C-K is an intestinal microbiota metabolite of ginsenoside Rb1, which possesses anti-proliferative and anti-inflammatory activities.
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Ginsenoside K; Ginsenoside compound K
1.Preparation of minor ginsenosides C-Mc, C-Y, F2, and C-K from American ginseng PPD-ginsenoside using special ginsenosidase type-I from Aspergillus niger g.848.
Liu CY1, Zhou RX2, Sun CK3, Jin YH4, Yu HS2, Zhang TY2, Xu LQ2, Jin FX2. J Ginseng Res. 2015 Jul;39(3):221-9. doi: 10.1016/j.jgr.2014.12.003. Epub 2014 Dec 31.
BACKGROUND: Minor ginsenosides, those having low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng protopanaxadiol (PPD)-ginsenoside was studied using special ginsenosidase type-I from Aspergillus niger g.848.
2.Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells.
Zheng Y1, Nan H2, Hao M3, Song C3, Zhou Y3, Gao Y1. Biomed Rep. 2013 Jul;1(4):555-558. Epub 2013 May 10.
Ginsenosides are the main biologically active components of ginseng. In this study, seven types of protopanaxadiol ginsenosides were assessed for their antiproliferative activity on the HCT-116 and HT-29 human colorectal cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The experimental results indicated that the native protopanaxadiol ginsenosides Rb1 and Rb2 inhibited the proliferation of the colorectal cancer cells in a dose-dependent manner. The deglycosylation products F2 and CO (from ginsenosides Rb1 and Rb2, respectively) significantly inhibited the growth of the human colorectal cancer cell lines, whereas product C-K (from Rb1 and Rb2) exerted no antiproliferative effects on the cancer cell lines assessed in this study. HT-29 cells were more sensitive to these ginsenosides compared to HCT-116 cells. In addition, the antiproliferative activity of ginsenosides was found to be correlated with the number and type of sugar residues.
3.Sphingobacterium ginsenosidimutans sp. nov., a bacterium with ginsenoside-converting activity isolated from the soil of a ginseng field.
Son HM1, Yang JE, Kook MC, Shin HS, Park SY, Lee DG, Yi TH. J Gen Appl Microbiol. 2013;59(5):345-52.
A Gram-staining-negative, aerobic, non-motile, non-spore-forming, and rod-shaped bacterium designated THG 07(T) was isolated from the soil of a ginseng field of Pocheon in South Korea, and its taxonomic position was investigated by using a polyphasic study. Strain THG 07(T) grew optimally at 25-30°C and at pH 6.5-7.0 and in the absence of NaCl on nutrient agar. Strain THG-T17(T) displayed β-glucosidase activity that was responsible for its ability to transform ginsenoside Rb1 (one of the dominant ginsenosides of ginseng) to compound C-K. On the basis of 16S rRNA gene sequence similarity, strain THG 07(T) was shown to belong to the family Sphingobacteriaceae and was related to Sphingobacterium canadense CR11(T) (98.7%), S. cladoniae No.6(T) (98.1%), S. detergens 6.2S(T) (98.0%), S. multivorum IAM14316(T) (97.9%), S. siyangense SY1(T) (97.8%) and S. thalpophilum DSM11723(T) (96.9%). The G+C content of the genomic DNA was 40.6 mol%. The major menaquinone, MK-7, and major fatty acids, iso-C₁₅:₀ and C₁₆:₁ ω7c and/or ω6c, supported the affiliation of strain THG 07(T) to the genus Sphingobacterium.
4.Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-induced arthritis.
Liu KK1, Wang QT1, Yang SM1, Chen JY1, Wu HX1, Wei W1. Acta Pharmacol Sin. 2014 May;35(5):599-612. doi: 10.1038/aps.2014.7. Epub 2014 Apr 14.
AIM: To investigate the anti-arthritis and immunomodulatory activities of ginsenoside compound K (C-K) in mice with collagen-induced arthritis (CIA).
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CAS 39262-14-1 Ginsenoside C-K

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