Ginkgolide C - CAS 15291-76-6
Catalog number:
15291-76-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H24O11
Molecular Weight:
440.40
COA:
Inquire
Targets:
Platelet-activating factor receptor (PAF-R)
Description:
Ginkgolide C, extracted from the Ginkgo biloba leaves, a traditional Chinese medicine, significantly increases the formation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and studies showed that when platelets (108/ml
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
Ginkgolide C 15291-76-6 1,7-Dihydroxy-ginkgolide A Ginkgolide C; GINKGOKIDE C AC1L4OUG AC1Q6PCW CTK8F0397 AR-1C0541 AR-1C0542 NSC335757 AN-8390 NSC-335757 TR-031689 N1908 L001208 I06-0420 (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -59℃ for long term (months to years).
MSDS:
Inquire
Quality Standard:
Enterprise Standard
Shelf Life:
2 years
Quantity:
Grams-Kilos
Boiling Point:
813.8±65.0 °C | Condition: Press: 760 Torr
Density:
1.72±0.1 g/cm3
InChIKey:
AMOGMTLMADGEOQ-UHFFFAOYSA-N
InChI:
1S/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3
Canonical SMILES:
CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5O)C(C)(C)C)C(C(=O)OC6O4)O)O
1.GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides.
Ng CC1, Duke RK1, Hinton T1, Johnston GA2. Eur J Pharmacol. 2016 Apr 15;777:136-46. doi: 10.1016/j.ejphar.2016.03.007. Epub 2016 Mar 4.
The terpenoid lactones from Ginkgo biloba, bilobalide and ginkgolides, have been shown to act as negative modulators at α1β2γ2L GABAA receptors. They have structural features similar to those of the chloride channel blocker picrotoxinin. Unlike picrotoxinin, however they are not known to produce convulsant effects. Using two-electrode voltage clamp electrophysiology, this study compared the effect of mutation of 2', 6' and 15' pore facing M2 domain residues to cysteine on the action of picrotoxinin, bilobalide and ginkgolides at α1β2γ2L GABAA receptors expressed in Xenopus oocytes. Picrotoxinin was affected by mutation differently from the ginkgo terpenoid lactones. Although some of these compounds were affected by the mutation at same position and/or subunit, the changes in their potency were found to be dissimilar. The results suggest that the intracellular pore binding site for picrotoxinin, bilobalide, ginkgolide A, ginkgolide B and ginkgolide C is comprised of 2'β-6'β6'γ, 2'α2'β-6'α6'β, 2'α2'β2'γ-6'β6'γ, 2'α, 2'β2'γ-6'β and 2'α2'β, respectively.
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CAS 15291-76-6 Ginkgolide C

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