Ginkgolide A - CAS 15291-75-5
Catalog number:
15291-75-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H24O9
Molecular Weight:
408.4
COA:
Inquire
Targets:
GABA Receptor
Description:
Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
BN52020
MSDS:
Inquire
1. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
Tomohiro Nabekura • Takeshi Yamaki • Kazuyuki Ueno • Shuji Kitagawa. Cancer Chemother Pharmacol (2008) 62:867–873
The ingredients of sesame, ginkgo, and soybean are now widely used in commercially available dietary supplements. Sesamin, a lignan existing exclusively and abundantly in sesame (Sesamum indicum) seeds, is thought to have antioxidative activity and hypocholesteromic eVects. Sesamin is a common ingredient of dietary supplements, especially in Japan. Ginkgo (Ginkgo biloba) leaf extracts containing ginkgolide A, B, and C, and bilobalide are reported to provide protection against neural and vascular damage [12]. Ginkgo leaf extracts are available as medical drugs in Europe, and as herbal preparations in other countries. Soybean (Glycine max) products containing isoXavones such as genistein, daidzein and glycitein, and lignan matairesinol are also well consumed as dietary supplements or foods such as tofu and soy sauce. Licorice (Glycyrrhiza glabra) extract containing glycyrrhizin, glycyrrhetinic acid, glabridin, liquiritigenin, and isoliquiritigenin is one of the major components of traditional Chinese medicine . Licorice extracts are also widely used as sweetening agents for foods such as soy sauce and licorice candy. Phyllodulcin from Amacha (Hydrangea macrophylla var. thunbergii), and stevioside, steviol, and isosteviol from Stevia (Stevia rebaudiana) are used as food sweeteners.
2. Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract(EGb 761) during ischemia and reperfusion
Thibaut Liebgott, Malvina Miollan, Yves Berchadsky, Katy Drieu, Marcel Culcasi, Sylvia Pietri. Basic Res Cardiol 95: 368 – 377 (2000)
With further regard to this cardioprotective role of the terpenoid constituents of EGb 761, a series of studies conducted with hypoxic cultured endothelial cells treated with bilobalide, with ischemic-reperfused isolated hearts, or with heart mitochondrial preparations from rats that had been pretreated orally with ginkgolide A or bilobalide have recently indicated they might act at the membrane and/or at the mitochondrial levels during the pre-ischemic period. This hypothesis is in accord with the present observation that the ventricular contracture that occurred during ischemia was significantly suppressed in hearts that were exposed to ginkgolides or to a low concentration of EGb 761, as compared to untreated hearts (Table 1). Although an in vitro O2•–scavenging activity of the terpenoid constituents of EGb 761 (except for ginkgolide A) in a lipophilic environment has been recently reported, the published second-order rate constants are relatively modest. Hence, direct O2•–-trapping within the membrane of the ischemic-reperfused heart does not seem to be a relevant mechanism for explaining their cardio-protective action.
3. Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide
Connie W.H. Woo, Filly Cheung, Vincent W.H. Chan, Yaw L. Siow and Karmin O. Molecular and Cellular Biochemistry 243: 37–47, 2003
Next, we investigated the effect of EGb and its terpenoids on homocysteine-induced iNOS expression in macrophages. As shown in Fig. 3A, EGb at the concentration of 100 µg/mL or ginkgolide A, ginkgolide B and bilobalide at the concentration of 0.5 µg/mL completely abolished homocysteine-stimulated iNOS activation. Further analysis revealed that EGb, ginkgolide A, ginkgolide B or bilobalide treatment also blocked homocysteine-induced iNOS protein and iNOS mRNA expression in macrophages (Figs 3B and 3C). Addition of SOD (300 units/mL) to the culture medium also completely abolished homocysteine-stimulated iNOS activity and expression (Fig. 3).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related GABA Receptor Products


BAR-501
(CAS: 1632118-69-4)

BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overex...

CAS 951650-22-9 NS 11394

NS 11394
(CAS: 951650-22-9)

NS 11394 is a drug with selectivity for the α3 and α5 subtypes. It acts as a subtype-selective positive allosteric modulator at GABAA receptors. It is used as a...

TPA023
(CAS: 252977-51-8)

TPA023, also called as MK-0777, is a subtype-selective, mixed agonist-antagonist at GABAA receptor with anxiolytic and anticonvulsant effects.

CI966
(CAS: 110283-79-9)

CI966 is a highly potent and selective blocker of the GABA transporter 1 (GAT-1) with IC50 value of 0.26 µM acting as a central nervous system depressant. It ha...

CAS 68547-97-7 Isoguvacine hydrochloride

Isoguvacine hydrochloride
(CAS: 68547-97-7)

Isoguvacine hydrochloride is a selective GABA receptor agonist with anticonvulsant and antiepileptic effect, developed for Neuroscience research.

CAS 15291-75-5 Ginkgolide A

Ginkgolide A
(CAS: 15291-75-5)

Ginkgolide A is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a Ki of 14.5 μM.

Remimazolam benzenesulfonat
(CAS: 1001415-66-2)

Remimazolam, a novel Benzodiazepine derivatives, has potential use for anxiolytic, sedative and hypnotic. For the reason that remimazolam's beding discontinued ...

CAS 69308-37-8 (R)-baclofen

(R)-baclofen
(CAS: 69308-37-8)

(R)-baclofen a selective GABAB agonist.

CP-457920
(CAS: 220860-50-4)

CP-457920, also called as NGD 971, is a selective α5 GABAA receptor inverse agonist (Ki of ~ 1 ng/mL). CP-457920 was progressed into clinical studies for the tr...

CAS 783331-24-8 MRK 016

MRK 016
(CAS: 783331-24-8)

MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator with EC50 value of 3 nM. It has nootropic properties. MRK-016 can produce rapid...

CAS 847353-30-4 Arbaclofen placarbil

Arbaclofen placarbil
(CAS: 847353-30-4)

Arbaclofen placarbil is a prodrug of R-baclofen. It is a GABA B receptor agonist. Arbaclofen was being developed as a potential treatment for patients with GERD...

CAS 1134-47-0 Baclofen

Baclofen
(CAS: 1134-47-0)

Baclofen, an agonist of GABAB receptor, could be effective as a skeletal muscle relaxant and has been also found to have antispastic effect.

CAS 56776-32-0 Etifoxine Hydrochloride

Etifoxine Hydrochloride
(CAS: 56776-32-0)

Etifoxine Hydrochloride is Potentiator of GABAA receptor with anxiolytic and anticonvulsant activity.

CAS 155569-91-8 Emamectin Benzoate

Emamectin Benzoate
(CAS: 155569-91-8)

Emamectin Benzoate is the Emamectin derivative. Emamectin, also called as Proclaim, is widely used as an insecticide because of its chloride channel activation ...

CAS 138729-47-2 Eszopiclone

Eszopiclone
(CAS: 138729-47-2)

Eszopiclone is an active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Eszopiclone is a GABA A rece...

CAS 77472-98-1 Pipequaline

Pipequaline
(CAS: 77472-98-1)

Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodiazepine class. It exhibits anxioly...

CAS 188116-07-6 AWD 131-138

AWD 131-138
(CAS: 188116-07-6)

CAS 62666-20-0 Progabide

Progabide
(CAS: 62666-20-0)

Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is...

Pipequaline HCl

The hydrochloride of pipequaline. Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodi...

CAS 1758-80-1 L-DABA

L-DABA
(CAS: 1758-80-1)

L-DABA, (L-2,4-Diaminobutyric acid) is a noncompetitive GABA transaminase inhibitor (IC50> 500 μM) with antitumor activity in vivo and in vitro.

Chemical Structure

CAS 15291-75-5 Ginkgolide A

Quick Inquiry

Verification code

Featured Items