GIBH-130 - CAS 1252608-59-5
Category: Inhibitor
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Molecular Formula:
C20H20N6O
Molecular Weight:
360.41
COA:
Inquire
Targets:
Interleukin Related
Description:
GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses theIL-1βsecretion by activated microglia (IC50=3.4 nM). GIBH-13 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents.
Synonyms:
(4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2; -ylpiperazin-1-yl)methanone; (4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone; GIBH-130; GIBH130; GIBH 130
Solubility:
10 mM in DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
664.5±65.0 ℃ at 760 Torr
Density:
1.268±0.06 g/cm3
InChIKey:
ZTJHTEHADIHZJS-UHFFFAOYSA-N
InChI:
1S/C20H20N6O/c1-15-14-17(16-6-3-2-4-7-16)23-24-18(15)19(27)25-10-12-26(13-11-25)20-21-8-5-9-22-20/h2-9,14H,10-13H2,1H3
Canonical SMILES:
CC1=CC(=NN=C1C(=O)N2CCN(CC2)C3=NC=CC=N3)C4=CC=CC=C4
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Chemical Structure

CAS 1252608-59-5 GIBH-130

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