GFT505 - CAS 824932-88-9
Catalog number: 824932-88-9
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H24O4S
Molecular Weight:
384.49
COA:
Inquire
Targets:
PPAR
Description:
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. It induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. It is a dual PPARα/δ agonist that has demonstrated efficacy in disease models of nonalcoholic fatty liver disease (NAFLD)/NASH and liver fibrosis. It confers liver protection by acting on several pathways involved in NASH pathogenesis, reducing steatosis, inflammation, and fibrosis.
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Purity:
>98%
Appearance:
Light yellow to yellow Solid
Synonyms:
Elafibranor;(E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid;2-(2,6-dimethyl-4-{3-[4-(methylsulfanyl)phenyl]-3-oxoprop-1-en-1-yl}phenoxy)-2-methylpropanoic acid
Solubility:
DMSO: ≥ 33 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. It confers liver protection by acting on several pathways involved in NASH pathogenesis, reducing steatosis, inflammation, and fibrosis.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
569.0±50.0 °C | Condition: Press: 760 Torr
Density:
1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChI:
InChI=1S/C22H24O4S/c1-14-12-16(13-15(2)20(14)26-22(3,4)21(24)25)6-11-19(23)17-7-9-18(27-5)10-8-17/h6-13H,1-5H3,(H,24,25)/b11-6+
Canonical SMILES:
CC(C)(OC1=C(C)C=C(/C=C/C(C2=CC=C(SC)C=C2)=O)C=C1C)C(O)=O
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