Genz-123346 - CAS 491833-30-8
Catalog number: 491833-30-8
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
COA:
Inquire
Targets:
Others
Description:
Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
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Synonyms:
Genz-123346; Genz123346; Genz 123346
MSDS:
Inquire
Current Developer:
Genzyme.
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CAS 491833-30-8 Genz-123346

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