Genistin - CAS 529-59-9
Catalog number:
529-59-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H20O10
Molecular Weight:
432.38
COA:
Inquire
Targets:
Others
Description:
Genistinis, a derivative of Genistein, is selective inhibitor of mammalian terminal deoxynucleotidyl transferase.
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Purity:
≥98%
Appearance:
Off-White to Grey Solid
Synonyms:
4',5,7-Trihydroxyisoflavone 7-glucoside;Genistein 7-glucoside;Genistein-7-O-beta-D-glucopyranoside;5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A phytoestrogen
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
274-276 ºC
InChIKey:
ZCOLJUOHXJRHDI-CMWLGVBASA-N
InChI:
1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
Canonical SMILES:
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)OC4C(C(C(C(O4)CO)O)O)O)O
1.Cardioprotective Effects of Genistin in Rat Myocardial Ischemia-Reperfusion Injury Studies by Regulation of P2X7/NF-κB Pathway.
Gu M1, Zheng AB1, Jin J1, Cui Y1, Zhang N1, Che ZP1, Wang Y1, Zhan J1, Tu WJ2. Evid Based Complement Alternat Med. 2016;2016:5381290. doi: 10.1155/2016/5381290. Epub 2016 Mar 20.
The present study aimed to assess the effects and mechanisms of genistin in the rat model of myocardial ischemia reperfusion injury. The rat hearts were exposed to the left anterior descending coronary artery (LAD) ligation for 30 min followed by 1 h of reperfusion. In the rat of myocardial ischemia/reperfusion (MI/R), it was found that genistin pretreatment reduced myocardial infarct size, improved the heart rate, and decreased creatine kinase (CK) and lactate dehydrogenase (LDH) levels in coronary flow. This pretreatment also increased catalase (CAT), superoxide dismutase (SOD) activities but decreased glutathione (GSH), malondialdehyde (MDA) levels. Furthermore, we determined that genistin can ameliorate the impaired mitochondrial morphology and oxidation system; interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α) levels were also recovered. Besides, related-proteins of nuclear factor kappa-B (NF-κB) signal pathway activated by P2X7 were investigated to determine the molecular mechanism of genistin and their expressions were measured by western blot.
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CAS 529-59-9 Genistin

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