|Description||Geldanamycin is a benzoquinone ansamycin antibiotic isolated from streptomyces hygroscopicus. It acts as a potent antitumour agent by binding to the 90-kda heat-shock protein (hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase htert.|
|B1335-476260||200 mg||$198||In stock|
|B1335-476260||500 mg||$398||In stock|
|Purity||>99% by HPLC|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.|
Macrocyclic lactone belonging to the oligomycin class but identified from different species of streptomyces; inhibits mitochondrial F1F0-atpase; an important bi...
A member of a potent family of macrocyclic lactones; broadly active against bacteria, fungi, insects, nematodes and protozoans; a potential agent for treating o...
Cyclo(L-Phe-trans-4-hydroxy-L-Pro) is a cyclodipeptide from the fermentation broth of Streptomyces sp. YIM67005.
Enramycin is a polypeptide antibiotic produced by streptomyces fungicidus. It was developed as a food additive in Japan. Enramycin is composed of two different ...
An unusual depsipeptide featuring a pentaenone side chain; reported as an antiviral; has potent antibacterial activity against gram positive and gram negative b...
A potent antitumour antibiotic isolated from a streptomyces species; a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour ...
A minor component of the leptomycin complex produced by some streptomyces sp.; an hydroxylated analogue of leptomycin A, a nuclear export inhibitor; displays po...
The dominant analogue of a class macrocyclic lactones isolated from selected strains of streptomyces sp.; an inhibitor of mitochondrial F1F0-atpase; induces apo...