Geldanamycin - CAS 30562-34-6
Catalog number: B1335-476260
Category: Metabolites
Molecular Formula:
C29H40N2O9
Molecular Weight:
560.6
COA:
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source\Analogue Sets:
Streptomyces
Description:
Geldanamycin is a benzoquinone ansamycin antibiotic isolated from streptomyces hygroscopicus. It acts as a potent antitumour agent by binding to the 90-kda heat-shock protein (hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase htert.
Ordering Information
Catalog Number Size Price Stock Quantity
B1335-476260 200 mg $198 In stock
B1335-476260 500 mg $398 In stock
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Purity:
>99% by HPLC
Appearance:
Yellow Solid
Synonyms:
[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
Solubility:
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
MSDS:
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InChIKey:
QTQAWLPCGQOSGP-KSRBKZBZSA-N
InChI:
InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
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CAS 30562-34-6 Geldanamycin

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