|Molecular Formula||C10H15N5O10P2S (free acid)|
|Molecular Weight||459.26 (free acid)|
|Structure\Application||Phosphate modified Nucleotides | Nucleotides applied on Proteins/Enzymes|
|Description||GDPβS has been found to exhibit activities as an inhibitor of G-coupled protein.|
|Purity||≥ 90 % by HPLC|
|Related CAS||97952-36-8 (Lithium salt)|
|Synonyms||Guanosine-5'-(β-thio)-diphosphate, Sodium salt|
GpCp is an analogue of GDP and has been found to be hydrolytically stable.
ddGTP-α-S is used in mass spectrometric genotyping.
8-Bromo-GTP is a GTP analog that can inhibit GTP-hydrolase. It competitively inhibits GTPase (IC50 = 32 μM) and competes with ATP for the binding center of RNA-...
ATPγS is an agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11). It has been used to identify kinase substrates, used as a reagent in...
6-Thio-GTP is a Vac-1-Rac signaling inhibitor that inhibits TNF-α-induced downstream signaling via JNK. It exhibits immunosuppressant effects.
GTPαS can be accomplished by 50-thiophosphorylation of 7-methylguanosine in (MeO)3PO in the presence of 2,6-lutidine,12 followed by addition of tributylammonium...
5-Iodo-dUTP is used in the synthesis of Texas Red-5-dUTP, a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of re...