GDC-0941 dimethanesulfonate - CAS 957054-33-0
Catalog number:
957054-33-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H35N7O9S4
Molecular Weight:
705.85
COA:
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Targets:
PI3K
Description:
GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with modest selectivity against p110β and p110γ. It is a novel selective class I phosphatidylinositol-3-kinase (PI3K) inhibitor. It is designed to bind the ATP-binding pocket of PI3K and to prevent formation of phosphatidylinositol-3, 4, 5-triphosphate (PIP3), a second messenger that transmits PI3K downstream signals. It causes growth inhibition in a variety of cancer cell lines, including A2780, MDA-MB-361, PC3, and U87MG. It also inhibits the growth of trastuzumab–sensitive and –resistant HER2-amplied cancer cells which harbor p110( mutations or PTEN loss. It also reduces tumor volume in different xenograft models.
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Purity:
>98%
Synonyms:
Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt)
MSDS:
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CAS 957054-33-0 GDC-0941 dimethanesulfonate

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