GDC-0425 - CAS 1200129-48-1
Catalog number: 1200129-48-1
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H19N5O
Molecular Weight:
321.38
COA:
Inquire
Targets:
Checkpoint Kinase (Chk)
Description:
This active molecular is an selective Checkpoint kinase 1 (Chk1) inhibitors and it enhances gemcitabine efficacy in tumor xenograft models. GDC-0425 was safe and yielded responses in patients with a variety of cancers. In Oct 2013, GDC 0425 was in phase I trials for Solid tumours and Lymphoma (late-stage disease) in USA and France. In May 2014, Genentech completed a phase I trial in Lymphoma and Solid tumours (late-stage disease) in USA and France.
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Purity:
98%
Appearance:
Powder
Synonyms:
5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile;RG-7602
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Solid tumours and Lymphoma
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
N#CC1=NC=C2C(C3=CC=CN=C3N2)=C1OC4CCN(CC)CC4
Current Developer:
Originator:Genentech
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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