GDC-0084 - CAS 1382979-44-3
Catalog number: B0084-474534
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H22N8O2
Molecular Weight:
382.19
COA:
Inquire
Targets:
mTOR | PI3K
Description:
GDC-0084, a PI3K inhibitor, has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. It was just licensed to Novogen and start a Phase II trial for Glioma.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-474534 300 mg $599 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
GDC-0084; 5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine
Solubility:
DMSO: ≥ 6 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
GDC-0084 is a PI3K inhibitor that has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
LGWACEZVCMBSKW-UHFFFAOYSA-N
InChI:
InChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
Canonical SMILES:
CC1(C2=NC3=C(N2CCO1)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N)C
Current Developer:
Novogen
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mTOR Products


CAS 1431697-74-3 CAL-130

CAL-130
(CAS: 1431697-74-3)

CAL-130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3-kinase (PI3K)/Akt activatio...

GSK-2269557 HCl salt
(CAS: 1254036-77-5)

GSK-2269557 is a selective Phosphatidylinositol 3 kinase delta inhibitor originated by GlaxoSmithKline. GSK-2269557 is highly selective for PI3Kδ over the close...

PQR530
(CAS: 1927857-61-1)

PQR530 is a potent dual pan PI3K/mTOR inhibitor undergoing phase II clinical trials in 2016. Aberrant activation of the PI3K/mTOR signaling pathway promotes the...

CAS 6724-53-4 Perhexiline maleate salt

Perhexiline maleate salt
(CAS: 6724-53-4)

Perhexiline maleate salt is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor. It is an anti-anginal metabolic modulator and used in treatments for a...

CAS 1251156-08-7 XL388

XL388
(CAS: 1251156-08-7)

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhib...

Duvelisib R enantiomer
(CAS: 1261590-48-0)

The R isomer analogue of Duvelisib which is a high selective PI3K δ/γ inhibitor.

CAS 956958-53-5 XL147

XL147
(CAS: 956958-53-5)

Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family o...

CAS 474012-90-3 CAL-130 Racemate

CAL-130 Racemate
(CAS: 474012-90-3)

CAL-130 racemate is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kγ/δ as therapy for T cell acute lymphobla...

CAS 1062161-90-3 WYE-687

WYE-687
(CAS: 1062161-90-3)

WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.

CAS 938444-93-0 D 106669

D 106669
(CAS: 938444-93-0)

D 106669 is a potent and selective PI3K inhibitor.

Seletalisib
(CAS: 1362850-20-1)

Seletalisib is a selective Phosphatidylinositol 3 kinase delta inhibitor originated by UCB.It is a Immunomodulator. Phaes I clinical trials for Plaque psoriasis...

CAS 1007207-67-1 CH5132799

CH5132799
(CAS: 1007207-67-1)

CH5132799 is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3K; (IC(50)=0.014 uM). In human tumor cell lines ...

CAS 914913-88-5 Palomid 529

Palomid 529
(CAS: 914913-88-5)

Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt ...

CAS 1009298-09-2 AZD-8055

AZD-8055
(CAS: 1009298-09-2)

AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/t...

CAS 371935-74-9 PI-103

PI-103
(CAS: 371935-74-9)

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α...

SAR-405
(CAS: 1523406-39-4)

SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50= 1.2 nM, Kd= 1.5 nM) without disrupting other PI3K...

DMH-25
(CAS: 1685280-21-0)

DMH-25, a chromene derivative, could be a covalent mTOR inhibitor that has be found to exhibit activity in restraining the growth and metastasis of triple-negat...

CAS 1013098-90-2 PI3Kα/mTOR-IN-1

PI3Kα/mTOR-IN-1
(CAS: 1013098-90-2)

PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR (Kis= 10.6 nM and 12.5 nM for mTOR and PI3Kα, respectively).

AZD-8835
(CAS: 1620576-64-8)

AZD-8835 was selected as a clinical candidate for the treatment of PIK3CA-dependent cancers and is currently in phase I clinical trials. It is an orally bioavai...

CAS 159351-69-6 Everolimus

Everolimus
(CAS: 159351-69-6)

Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) with an immunosuppressive activity which is comparable to that of rapamycin. It inhibits cyto...

Quick Inquiry

Verification code

Featured Items