GDC-0077 - CAS 2060571-02-8
Category: Inhibitor
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Molecular Formula:
C18H19F2N5O4
Molecular Weight:
407.37
COA:
Inquire
Targets:
PI3K
Description:
GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
Brife Description:
An orally available PI3K inhibitor
Synonyms:
GDC-0077; GDC 0077; GDC0077. (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
Solubility:
DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
698.0±65.0 ℃ at 760 Torr
Density:
1.63±0.1 g/cm3
InChIKey:
SGEUNORSOZVTOL-CABZTGNLSA-N
InChI:
1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1
Canonical SMILES:
CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F
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Chemical Structure

CAS 2060571-02-8 GDC-0077

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